肝动脉化疗栓塞联合射频消融在原发性肝癌中的价值

The Value of Hepatic Artery Chemoembolization Combined With Radiofrequency Ablation in Primary Liver Cancer

目的探讨肝动脉化疗栓塞(hepatic artery chemoembolization,TACE)联合射频消融术(radiofrequency ablation,RFA)在原发性肝癌患者中应用效果。方法在本院范围内,以2019年5月-2020年5月为时间节点,选取原发性肝癌患者90例,将其按照治疗方法的不同分为两组,对照组47例单纯行TACE术治疗,观察组43例基于此,联合RFA术治疗,对比两组治疗效果及肿瘤活性相关指标、肿瘤复发相关指标。结果观察组治疗总有效率(88.37%)与对照组(72.34%)比较差异无统计学意义(P>0.05)。观察组治疗后血管内皮生长因子(vascular endothelial growth factor,VEGF)、E-钙蛋白(E-calcin,EC)、基质金属蛋白酶(matrix metalloproteinase,MMP)、谷氨酸转移酶(glutamate transferase,GGT)、糖链抗原19-9(sugar chain antigen 19-9,CA199)、甲胎蛋白(alpha-fetoprotein,AFP)相比对照组,均显著偏低(P<0.05)。结论针对原发性肝癌患者,行TACE结合RFA治疗,可进一步提高疗效。

Objective To investigate the effect of hepatic artery chemoembolization(TACE)combined with radiofrequency ablation(RFA)in patients with primary liver cancer.Methods Within the scope of our hospital,90 patients with primary liver cancer were selected from May 2019 to May 2020.They were divided into two groups according to different treatment methods.47 patients in the control group were treated with TACE alone and 43 patients in the observation group were treated with RFA.Based on this,the treatment effects,tumor activity and tumor recurrence of the two groups were compared.Results There was no statistically significant difference in the total effective rate between the observation group(88.37%)and the control group(72.34%)(P>0.05).In the observation group,vascular endothelial growth factor(VEGF),E-calcin(EC),matrix metalloproteinase(MMP),glutamate transferase(GGT),sugar chain antigen 19-9(CA199),alpha fetoprotein(AFP)was significantly lower than that in the control group(P<0.05).Conclusion TACE combined with RFA can further improve the curative effect in patients with primary liver cancer.