医用高分子材料表面机械抗菌研究进展

Research Progress of Mechanical Antibacterial on Medical Polymer Materials Surfaces

植入式医疗器械表面产生的细菌黏附可引起灾难性感染,给患者带来极大的痛苦和经济压力。在医疗器械改性时使用抗生素,细菌抗生素耐药性变得越来越大。与此同时,材料表面的化学修饰在防止细菌积聚和因此接近方面具有差的长期性能,通过机械表面形貌实现杀菌作用近年来变得越来越重要。当考虑纳米结构化杀菌表面的设计时,细菌细胞壁与纳米结构表面的相互作用的复杂性质代表了许多挑战。介绍了高分子材料表面改性后用于机械杀菌效果的进展,重点是了解纳米结构和细菌细胞壁之间的相互作用、有效的纳米结构杀菌表面的基本设计参数以及杀菌机理模型。

Bacteria that adhere to the surfaces of implanted medical devices can cause catastrophic infection,great pain and economic pressure. Bacterial antibiotic resistance has become an increasing use of antibiotics in the medical devices modified. Chemical modifications of material surfaces have poor long-term performance in preventing bacterial build-up,and hence approaches for realising bactericidal action through physical surface topography have become increasingly important in recent years. The complex nature of the bacteria cell wall interactions with nanostructured surfaces represents many challenges while the design of nanostructured bactericidal surfaces is considered. In this paper, the progress of the rear surface modified polymer materials for mechanical sterilization effect was briefly described, focusing on the interaction between the nanostructures and understanding bacterial cell wall, the basic design parameters of the effective surface sterilization nanostructure, and sterilization mechanism model.