葛根素治疗糖尿病及其并发症研究进展

Advancement of puerarin on the treatment of diabetes mellitus and its complications

糖尿病是一种以高血糖为特征的代谢性疾病,能够引起一系列严重的并发症。近年来,糖尿病患者数量持续增长,为国家和个人造成了极大负担。葛根素是提取自中药葛根中的一种有效成分,对糖尿病及其并发症的治疗具有一定优势。大量试验和临床研究证实,葛根素具有降低胰岛素抵抗,减轻炎性反应,改善局部微循环,抑制血小板聚集等多方面药理作用,对糖脂代谢异常、糖尿病肾病、糖尿病周围神经病变、糖尿病性心脏病、糖尿病骨病、糖尿病性视网膜病变、糖尿病足、妊娠糖尿病,以及由糖尿病引起的肺损伤、骨骼肌萎缩与认知障碍均具有确切疗效,值得被深入研究开发。

Diabetes is a metabolic disease characterized by hyperglycemia,which can cause a series of serious complications.In recent years,the number of patients with diabetes continues to grow,causing great burden for the country and individuals.Puerarin is an effective component extracted from Pueraria lobata,which has certain advantages in the treatment of diabetes and its complications.A large number of experiments and clinical studies have confirmed that puerarin has many pharmacological effects,such as reducing insulin resistance,lowering inflammatory reaction,improving local microcirculation and inhibiting platelet aggregation.Puerarin is effective in the treatment of abnormal glucose and lipid metabolism,diabetic nephropathy,diabetic peripheral neuropathy,diabetic heart disease,diabetic bone disease,diabetic retinopathy,diabetic foot,gestational diabetes mellitus,and lung injury,skeletal muscle atrophy and cognitive impairment caused by diabetes.It is worthy of further research and development.