淋巴上皮瘤样癌分子病理研究进展

Progress in molecular pathology of lymphoepithelioma-like carcinoma

淋巴上皮瘤样癌(LELC)是一组少见的与病毒感染密切相关的上皮性恶性肿瘤,可发生于全身任何器官。由于发病率低,LELC大样本临床研究缺乏,其发生的病因、发病机制、临床病理及分子病理特点尚不明确。该文就上述几方面进行文献综述,以期能够更好地了解LELC的发病及分子病理特征。

Lymphoepithelioma-like carcinoma(LELC)is a group of rare epithelial malignant tumors closely related to viral infection,which may occur in any organ of the body.Due to its low incidence,large scale clinical trials of LELC are lacking.The etiology,pathogenesis,clinicopathological and molecular pathological features of LELC are still unclear.This paper reviews the literature on the above aspects to better understand the pathogenesis and molecular pathological features of LELC.