Trap1在乳腺导管内增生性病变中的表达

Expression of Trap1 in breast intraductal proliferative lesions

目的:检测肿瘤坏死因子受体相关蛋白1(tumor necrosis factor receptor-associated protein 1,Trap1)在乳腺导管内增生性病变中的表达情况。方法:采用免疫组织化学方法检测Trap1在40例普通型导管增生(usual ductal hyperplasia,UDH),13例不典型导管增生(atypical ductal hyperplasia,ADH)及50例导管原位癌(ductal carcinoma in situ,DCIS)中的表达情况。结果:Trap1在UDH中弱阳性、中等阳性、强阳性表达率分别为75%、25%、0%;Trap1在ADH中弱阳性、中等阳性、强阳性表达率分别为0%、61.5%、38.5%;Trap1在DCIS中弱阳性、中等阳性、强阳性表达率分别为0%、40%、60%;Trap1在UDH中表达明显低于ADH和DCIS(P<0.05),Trap1在ADH和DCIS中的表达无差异(P>0.05);雌激素受体(estrogen receptor,ER)在UDH中阴性表达率为80%,在DCIS中弥漫强阳性表达率为90%,Trap1与ER在UDH和DCIS中的表达均呈正相关(P<0.05);ER在ADH中弥漫强阳性表达率为69.2%,与Trap1的表达无相关性(P>0.05)。结论:Trap1在UDH中表达明显低于ADH或DCIS,Trap1在UDH和DCIS中表达与ER呈正相关,有望成为鉴别UDH与ADH或DCIS的新指标。

Objective:To evaluate the expression of tumor necrosis factor receptor-associated protein 1(Trap1)in breast ductal proliferative lesions.Methods:The expression of Trap1 in usual ductal hyperplasia(UDH,n=40),atypical ductal hyperplasia(ADH,n=13),and ductal carcinoma in situ(DCIS,n=50)were detected by immunohistochemistry.Results:Weakly,moderately,and strongly positive expressions of Trap1 were noted in 75%,25%and 0%of UDH,respectively.However,the percentages of weakly,moderately,and strongly positive Trap1 expressions in ADH were 0%,61.5%and 38.5%,respectively.The percentages of weakly,moderately,and strongly positive Trap1 expressions in DCIS was 0%,40%and 60%,respectively.In conclusion,the expression of Trap1 in UDH was significantly lower than that in ADH and DCIS(both P<0.05).No significant difference of Trap1 expression was observed between ADH and DCIS(P>0.05).The negative percentage of estrogen receptor(ER)in UDH was 80%.The percentage of diffuse strong positive expression of ER in DCIS was 90%.The expressions of ER and Trp1 in UDH and DCIS were positive correlation(P<0.05).The percentage of diffusely strongly positive expression of ER in ADH was 69.2%.No correlation between ER and Trap1 in ADH was found(P>0.05).Conclusion:The expression of Trap1 in UDH is significantly lower than that in ADH or DCIS and the expressions of Trap 1 in UDH and DCIS are positively correlated with ER.Trap1 is expected to be a new biomarker for distinguishing UDH from ADH or DCIS.