TGF-β1基因多态性与骨密度和骨质疏松发生风险的相关性:荟萃分析

Association of TGF-β1 gene polymorphism with bone mineral density and risk of osteoporosis:A Meta-analysis

目的:系统评价转化生长因子-β1(transforming growth factor β1,TGF-β1)位点C509T、T869C、T29C多态性与骨密度及骨质疏松(osteoporosis,OP)的发生风险的相关性。方法:计算机检索PubMed、EMBASE、Web of Science及中国知网(CNKI)、维普(VIP)等数据库,时间均截至2020年4月,查找符合纳入与排除标准的相关研究。采用Newcastle-Ottawa(NOS)量表评估纳入文献的质量,运用RevMan 5.3进行统计学分析。结果:最终纳入16项研究,包括4748个研究对象。荟萃分析结果显示TGF-β1基因位点T869C多态性与亚洲人群OP的发生风险相关,C等位基因是OP发生的危险因素。T869C多态性也与骨密度相关,且亚组分析亚洲绝经后女性和男性人群中差异仍有统计学意义。在椎体骨密度方面,男性TT基因型>CC基因型>TC基因型,绝经后女性TT基因型>TC基因型。在股骨颈骨密度方面,男性T基因携带者>CC基因型,绝经后女性TT基因型>C基因携带者。结论:TGF-β1基因T869C位点多态性与OP的发生风险相关,与骨密度相关,尤其是亚洲人群,且在亚洲绝经后女性和男性人群中差异仍有统计学意义,可作为预测OP的遗传指标。

Objective:To systematically evaluate the association between the C509T,T869C,and T29C polymorphisms at transforming growth factorβ1(TGF-β1)locus with bone mineral density and the risk of osteoporosis.Methods:PubMed,EMBASE,Web of Science,CNKI,VIP and other databases were searched until April 2020,to find relevant studies that meet inclusion and exclusion criteria.The Newcastle-Ottawa scale was used to evaluate the quality of the included literature and RevMan5.3 software was used for statistical analysis.Results:Totally 16 studies were eventually included,including 4748 subjects.Meta-analysis showed that the T869C polymorphism of TGF-β1 gene was associated with the risk of osteoporosis in Asian populations.The C allele was a risk factor for OP.It was also associated with bone mineral density,and the subgroup analysis showed statistically significant differences no matter whether it was in postmenopausal women or men.In terms of vertebral bone mineral density,TT genotype>CC genotype>TC genotype was found in males,and TT genotype was greater than TC genotype in postmenopausal women.In terms of femoral neck bone mineral density,T gene carriers were found to be greater than CC genotype in males,and TT genotype was greater than C genotype in postmenopausal women.Conclusion:The T869C polymorphism of TGF-β1 gene is associated with the risk of osteoporosis and bone mineral density,especially in Asian populations,and the subgroup analysis showes statistically significant differences no matter whether it is in postmenopausal women or men,which can be used as a genetic indicator to predict osteoporosis.