自噬在狼疮性肾炎中的研究进展

Research progress of autophagy in lupus nephritis

狼疮性肾炎(lupus nephritis,LN)是系统性红斑狼疮(systemic lupus erythematosus,SLE)最严重和最常见的并发症之一。针对其潜在机制的研究,有助于认识病因和改进治疗。自噬是细胞内物质被运送到溶酶体或液泡进行降解的细胞过程。基于对自噬及LN各方面的研究,越来越多的证据证明了自噬和LN的关系。

Lupus nephritis(LN)is one of the most severe and common complications of systemic lupus erythematosus(SLE).There has been extensive studies on its underlying mechanisms,which helps to gain knowledge about its causes and treatment.Autophagy is a cellular process in which intracellular contents are transported to lysosomes or vacuoles for degradation.There is emerging evidence indicating the relationship between autophagy and LN based on research on various aspects of autophagy and LN.