门冬胰岛素注射液联合个体化医学营养疗法对妊娠期糖尿病孕妇胰岛素抵抗及ADMA、NO、NOS水平的影响

Effect of insulin aspart injection combined with individualized medical nutrition therapy on insulin resistance and ADMA,NO and NOS levels in pregnant women with gestational diabetes mellitus

目的探讨门冬胰岛素注射液联合个体化医学营养疗法对妊娠期糖尿病(GDM)孕妇胰岛素抵抗及ADMA、NO、NOS水平的影响。方法选择2015年1月至2020年1月我院收治的120例GDM孕妇作为研究对象,以治疗方案的不同将其分为对照组(60例,常规治疗+个体化医学营养疗法)和观察组(60例,常规治疗+个体化医学营养疗法+门冬胰岛素注射液)。比较两组的治疗效果。结果观察组的治疗总有效率为96.67%,高于对照组的86.67%(P<0.05)。治疗后,观察组的FINS水平、HOMA-IR低于对照组(P<0.05)。治疗后,观察组的ADMA水平低于对照组,NOS、NO水平高于对照组(P<0.05)。结论门冬胰岛素注射液联合个体化医学营养疗法治疗GDM的效果显著,可改善机体胰岛素抵抗,调节ADMA、NO、NOS水平,值得推广。

Objective To explore the effect of insulin aspart injection combined with individualized medical nutrition therapy on insulin resistanle and ADMA,NO and NOS levels in pregnant women with gestational diabetes mellitus(GDM).Methods A total of 120 pregnant women with GDM admitted in our hospital from January 2015 to January 2020 were selected as the research object and divided into control group(60 cases,conventional treatment+personalized medical nutrition therapy)and observation group(60 cases,conventional treatment+personalized medical nutrition therapy+insulin aspart injection)according to different treatment plans.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 86.67%in the control group(P<0.05).After treatment,the FINS level and HOMA-IR in the observation group were lower than those in the control group(P<0.05).After treatment,the ADMA level in the observation group was lower than that in the control group,and the levels of NOS and NO were higher than those in the control group(P<0.05).Conclusion Insulin aspart injection combined with individualized medical nutrition therapy in the treatment of GDM has a significant effect,it can improve body's insulin resistance,and regulate the levels of ADMA,NO,and NOS,which is worthy of promotion.