血尿酸对急性冠脉综合征行经皮冠脉介入术治疗患者的预后评估价值

The prognostic value of serum uric acid in patients with acute coronary syndrome after percutaneous coronary intervention

目的通过对行经皮冠脉介入术(PCI)治疗的急性冠脉综合征(ACS)患者进行急性冠脉事件的全球注册(GRACE)评分,探讨血清尿酸浓度对患者预后的评估价值。方法选取2018年1月至2019年12月嵊州市人民医院就诊并行PCI治疗的ACS患者226例,其中不稳定型心绞痛患者39例,急性非ST段抬高心肌梗死(NSTEMI)患者85例,急性ST段抬高心肌梗死(STEMI)患者102例。入院24 h内检查空腹血清尿酸浓度,尿酸≥428μmol/L的患者为观察组,<428μmol/L的患者为对照组。收集两组患者的一般资料,计算两组患者的GRACE评分,包括院内和出院6个月死亡风险评分、心肌梗死风险评分。结果两组患者一般资料比较,差异均无统计学意义(均P>0.05)。观察组的院内死亡风险、心肌梗死风险评分,院外6个月死亡风险、心肌梗死风险评分均高于对照组,差异均有统计学意义(均P<0.05)。结论血清尿酸浓度对ACS行PCI治疗患者的预后有一定的评估价值。

Objective To explore the value of serum uric acid in evaluating the prognosis of patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI),based on The Global Registry of Acute Coronary Events(GRACE)scores.Methods From January 2018 to December 2019 in Shengzhou People's Hospital,two hundred and twenty-six patients with ACS who underwent PCI were selected,including 39 patients with unstable angina,85 patients with acute non-ST segment elevation myocardial infarction(NSTEMI),and 102 patients with acute ST segment elevation myocardial infarction(STEMI).The serum uric acid(UA)level was detected within 24 hours after admission.Patients with UA≥428μmol/L were allocated to observation group,and those with UA<428μmol/L were allocated to control group.Basic clinical characteristics of the patients were collected.The in-hospital mortality risk score,six-month mortality risk score and myocardial infarction risk score were calculated by GRACE scoring system.The differences in risk scores between the two groups were compared.Results There was no significant difference in basic clinical characteristics between the observation and the control group(all P>0.05).The in-hospital mortality risk score,myocardial infarction risk score,six-month mortality risk score of the observation group were significantly higher than those of the control group(all P<0.05).Conclusion Serum uric acid level have prognostic value in patients with acute cornary syndrome undergoing PCI.