肿瘤减灭术后静脉腹腔联合化疗治疗晚期上皮性卵巢癌效果及对患者血清B7-H4蛋白、E-选择素水平的影响

Effect of intravenous intraperitoneal combined chemotherapy for advanced epithelial ovarian cancer after tumor reduction surgery and its effect on serum B7-H4 protein and E-selectin levels

目的:研究了肿瘤减灭术后静脉腹腔联合化疗治疗晚期上皮性卵巢癌(EOC)的效果及对血清B7-H4蛋白、E-选择素水平的影响。方法:纳入晚期EOC患者150例,均行肿瘤减灭术和静脉腹腔联合化疗。记录治疗有效率、治疗前后B7-H4蛋白、E-选择素水平。使用二元Logistic回归分析影响晚期EOC患者治疗反应的危险因素。使用ROC曲线分析B7-H4蛋白、E-选择素对晚期EOC患者治疗反应的预测价值。结果:肿瘤减灭术后静脉腹腔联合化疗对晚期EOC患者的治疗有效率为77.33%。治疗后患者B7-H4蛋白和E-选择素水平均明显低于治疗前(均P<0.05)。治疗前B7-H4蛋白水平、治疗前E-选择素水平、肿瘤减灭术后残余病灶直径≥1 cm均为晚期EOC患者治疗反应的独立影响因素(均P<0.05)。ROC曲线显示,B7-H4蛋白和E-选择素对晚期EOC患者治疗反应的预测中,AUC分别为0.727(95%CI:0.617~0.837)和0.799(95%CI:0.707~0.892)。结论:肿瘤减灭术后静脉腹腔联合化疗对晚期EOC患者的治疗有效率为77.33%,治疗前B7-H4蛋白、E-选择素水平均为晚期EOC患者治疗反应的独立影响因素,并可作为晚期EOC患者治疗反应预测的有效指标。

Objective:To study the effect of intravenous intraperitoneal combined chemotherapy for advanced epithelial ovarian cancer(EOC)after tumor reduction surgery and its effect on serum B7-H4 protein and E-selectin levels.Methods:150 patients with advanced EOC were included,all underwent tumor reduction surgery and intravenous intraperitoneal combined chemotherapy.The effective rate of treatment,B7-H4 protein and E-selectin levels before and after treatment were recorded.Binary Logistic regression was used to analyze the risk factors that affected the treatment response of patients with advanced EOC.The ROC curve was used to analyze the predictive value of B7-H4 protein and E-selectin on the treatment response of patients with advanced EOC.Results:The effective rate of intravenous intraperitoneal combined chemotherapy for patients with advanced EOC after tumor reduction surgery was 77.33%.After treatment,the patients’B7-H4 protein and E-selectin levels were significantly lower than those before treatment(all P<0.05).The level of B7-H4 protein before treatment,the level of E-selectin before treatment,and the residual lesion diameter≥1 cm after tumor reduction were all independent factors influencing the treatment response of patients with advanced EOC(all P<0.05).The ROC curve showed that the AUC of B7-H4 protein and E-selectin for the treatment response of patients with advanced EOC were 0.727(95%CI:0.617-0.837)and 0.799(95%CI:0.707-0.892),respectively.Conclusion:The effective rate of intravenous intraperitoneal combined chemotherapy for patients with advanced EOC after tumor reduction surgery was 77.33%.The levels of B7-H4 protein and E-selectin before treatment are independent factors influencing the treatment response of patients with advanced EOC,and can be used as effective indicators for the prediction of treatment response of patients with advanced EOC.