奥曲肽联合艾司奥美拉唑治疗非静脉曲张性上消化道出血的疗效观察

Efficacy of octreotide plus esomeprazole in non-variceal upper gastrointestinal bleeding

目的:比较奥曲肽联合艾司奥美拉唑与单独使用艾司奥美拉唑治疗非静脉曲张性上消化道出血的疗效。方法:选取2017年4月至2020年2月在广州市荔湾中心医院住院治疗的78例非静脉曲张性上消化道出血患者作为研究对象,按照随机数字表法分为联合组(奥曲肽联合艾司奥美拉唑,n=39)和对照组(单用艾司奥美拉唑,n=39)。比较两组总有效率、平均出血时间、再出血率、不良反应等指标。结果:联合组治疗后总有效率为94.9%,高于对照组的79.5%(P<0.05);联合组平均出血时间短于对照组(P<0.05);联合组再出血率低于对照组(P<0.05);两组患者治疗后均无不良反应。结论:奥曲肽联合艾司奥美拉唑治疗非静脉曲张性上消化道出血疗效显著,有利于降低再出血率、缩短出血时间。

Objective:To compare the efficacy of octreotide plus esomeprazole vs esomeprazole alone in the treatment of non-variceal upper gastrointestinal bleeding.Methods:Enrolled were 78 patients with non-variceal upper gastrointestinal bleeding in Liwan Central Hospital of Guangzhou between April 2017 and February 2020.The subjects were randomized into a combination group(octreotide plus esomeprazole,n=39)and a control group(esomeprazole alone,n=39)according to random number table.The total treatment respone,mean duration of bleeding,relapse of bleeding,and adverse reactions were compared between the two groups.Results:The total treatment response in the combination group was 94.9%,which was higher than that(79.5%)in the control group(P<0.05).The mean duration of bleeding in the combination group was shorter than that in the control group(P<0.05).Fewer patients in the combination group experienced relapse of bleeding compared with the control group(P<0.05).There were no adverse reactions in the two groups after treatment.Conclusion:Octreotide plus esomeprazole is significantly effective as a treatment of non-variceal upper gastrointestinal bleeding,with advantages in terms of less relapse of bleeding and shorter duration of bleeding.