高尿酸血症对代谢性疾病影响的纵向分析

Association of Hyperuricemia with Other Metabolic Diseases Using the Longitudinal Data

目的探讨高尿酸血症(hyperuricemia,HUA)对高血压、高脂血症和糖尿病等其他代谢性疾病的影响。方法应用齐齐哈尔市三甲医院体检中心2017~2019年连续3年体检人群纵向监测数据,共计2033例纳入标准,并对其人口学资料和生化指标采用χ^(2)检验和广义估计方程(generalized estimating equations,GEE)进行分析。结果分别以性别拟合3个GEE模型,逐步控制时间、年龄和相关指标后,HUA对高血压的影响:男性差异有统计学意义(OR=2.120,P<0.01),女性差异有统计学意义(OR=2.495,P<0.01);HUA对高脂血症的影响:男性差异有统计学意义(OR=2.864,P<0.01),女性差异有统计学意义(OR=3.655,P<0.01);HUA对糖尿病的影响:男性差异无统计学意义(OR=0.679,P>0.05),女性差异有统计学意义(OR=1.986,P<0.05)。结论HUA是高血压和高脂血症发病的危险因素,能够增加其发病风险,HUA可能对女性糖尿病的发病风险有影响。

Objective To explore the association of hyperuricemia(HUA)with impaired metabolic diseases such as hypertension,hyperlipidemia and diabetes mellitus.Methods From 2017 to 2019,a total of 2,033 subjects who underwent health checkups for three consecutive years from two hospitals in Qiqihar were selected.And its demographic data and biochemical indicators were analyzed usingχ^(2) test and generalized estimating equations(GEE).Results GEE indicated that odds ratio(OR)for hypertension was OR=2.120(P<0.01)in males and OR=2.495(P<0.01)in females,and OR for hyperlipidemia was OR=2.864(P<0.01)in males and OR=3.655(P<0.01)in females,but OR for diabetes mellitus was OR=0.679(P>0.05)in males and OR=1.986(P<0.05)in females for the hyperuricemia group in comparison with the normal group after controlling time,age and other factors.Conclusion The association of hyperuricemia with hypertension and hyperlipidemia is significant.Hyperuricemia is a risk factor of hypertension and hyperlipidemia.And it is also a risk factor of diabetes mellitus only in female subjects.