摘要
Hematopoietic stem cells(HSCs)are responsible for generating all blood cells throughout life.Apart from the role of HSCs in maintaining the homeostasis of blood cell production process,they must respond quickly to hematopoietic challenges,such as infection or blood loss.HSCs can be directly/indirectly activated and engage in blood formation for the acute needs in response to inflammation.Recent findings highlight the emerging role of inflammation signaling on HSC fate decision and shaping the hematopoietic system during aging.Here,we summarize recent studies identifying the changes in inflammation and their role in modulation of HSC function and discuss the interaction between inflammation and HSC biology in the contexts of aging and hematological malignancy.
基金
supported by grants 2016YFA0100602,2017YFA0103302 from the National Key Research and Development Programof China
Grants 81420108017,81525010,and 91749203 from and the National Natural Science Foundation of China
the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347)
Innovative Team Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110103002).
