丁苯酞辅助治疗症状性颅内动脉狭窄的临床效果观察

Clinical Effect of Butylphthalide in the Adjuvant Treatment of Symptomatic Intracranial Artery Stenosis

目的:研究丁苯酞辅助治疗症状性颅内动脉狭窄的效果,分析对神经功能及局部脑血流的影响。方法:选取100例症状性颅内动脉狭窄患者,使用数字表法随机分为两组,对照组47例,观察组53例。对照组患者给予血管内支架介入与拜阿司匹林、氯吡格雷、阿托伐他汀等基础治疗,观察组患者采用基础治疗联合丁苯酞治疗。比较两组患者治疗前和治疗2周后局部脑血灌注指标[病灶侧责任动脉相对局部脑血流量(rCBF)、相对局部脑血容量(rCBV)]、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]。结果:治疗2周后,两组患者rCBF、rCBV较治疗前均明显升高,且观察组显著高于对照组(P<0.05);两组患者NIHSS评分较治疗前均显著降低,且观察组明显低于对照组(P<0.05)。结论:丁苯酞辅助治疗症状性颅内动脉狭窄患者可有效改善患者神经功能和脑血流情况,对患者预后康复有利。

Objective:To study the efficacy of Butylphthalide in the adjuvant treatment of symptomatic intracranial artery stenosis and analyse its influence on neurological function and regional cerebral blood flow.Method:Totally 100 patients with symptomatic intracranial artery stenosis were selected and divided into two groups by using the digital table method,including 47 cases in the control group and 53 cases in the observation group.The patients in control group were given endovascular stent intervention and Bayaspirin,Clopidogrel and Atorvastatin,and the patients in observation group were combined with Butylphthalide for treatment on this basis.The regional cerebral blood perfusion indexes[relative regional cerebral blood flow (rCBF) and relative regional cerebral blood volume (rCBV) of offending artery of lesion side]and neurological function[National Institutes of Health stroke scale (NIHSS)]were compared between the two groups of patients before treatment and after 2 weeks of treatment.Result:After 2 weeks of treatment,the rCBF and rCBV of the two groups were significantly increased compared with those before treatment,and the above indexes of the observation group were significantly higher than those of the control group at the same time point (P<0.05).The NIHSS scores of the two groups of patients were significantly reduced compared to before treatment,and the score of the observation group was significantly lower than that in the control group (P<0.05).Conclusion:Butylphthalide in the adjuvant treatment of patients with symptomatic intracranial artery stenosis can effectively improve the neurological function and cerebral blood flow,and it is favorable for the prognosis recovery of patients.