内镜下氩离子凝固术治疗胃息肉对患者应激反应及血清G-17、PG水平影响

Influence on Stress Response and Serum G-17, PG Level in Patients with Gastric Polyps Treated with Endoscopic Argon Ion Coagulation

目的:探究内镜下氩离子凝固术治疗胃息肉对患者应激反应及血清胃泌素-17(gastrin-17,G-17)、胃蛋白酶原(pepsinogen,PG)水平的影响。方法:选取2019年4月-2021年1月在本院接受治疗的148例胃息肉患者作为本次的研究对象,对其临床资料进行回顾性分析,根据手术方案的不同将其分为两组:行高频电切术治疗的72例为对照组,行内镜下氩离子凝固术治疗的76例为观察组,对两组患者治疗前后的应激反应指标[去甲肾上腺素(norepinephrine,NE)、肾上腺素(epinephrine,E)、皮质醇(cortisol,Cor)]水平、G-17、PG水平的变化情况进行比较,并统计两组的术后并发症发生率。结果:治疗前,两组的应激反应水平、G-17、PG水平比较差异均无统计学意义(P>0.05)。治疗后,对照组的NE、E、Cor水平均高于观察组(P<0.05);两组治疗后PGⅡ水平比较差异无统计意义(P>0.05);两组治疗后G-17、PG-Ⅰ及PGR水平均高于治疗前(P<0.05);观察组治疗后G-17、PGⅠ及PGR水平均高于对照组(P<0.05)。两组的并发症发生率比较差异无统计学意义(P>0.05)。结论:内镜下氩离子凝固术治疗胃息肉患者可减轻机体的应激反应,并改善胃肠道环境,安全性良好。

Objective:To explore the influence in patients with gastric polyps treated by endoscopic argon ion coagulation on serum gastrin-17 (G-17) and pepsinogen (PG) levels.Method:A total of 148 patients with gastric polyps who were treated in our hospital from April 2019 to January 2021 were the observation objects of this study,and their clinical data were retrospectively analyzed,and they were divided into two according to different surgery procedures.Seventy-two cases underwent high-frequency resection treatment as the control group,seventy-six cases underwent endoscopic argon ion coagulation treatment as the observation group,the stress response indexes[norepinephrine the changes of norepinephrine (NE),epinephrine (E),cortisol (Cor)]levels of the two groups of patients before and after treatment,G-17,and PG levels were compared,and the incidence of postoperative complications in the two groups was calculated.Result:Before treatment,there were no statistically significant differences in the levels of stress response,G-17,and PG between the two groups (P>0.05).After treatment,the levels of NE,E,and Cor in the control group were higher than those in the observation group (P<0.05);the PGⅡ levels in the two groups after treatment were not statistically significant (P>0.05);the G-17,PGⅠ,PGⅡ and PGR levels in the two groups after treatment were higher than before treatment (P<0.05);G-17,PGⅠ and PGR levels after treatment in the observation group were higher than those in the control group (P<0.05).There was no significant difference in the incidence of complications between the two groups (P>0.05).Conclusion:Endoscopic argon ion coagulation treatment of patients with gastric polyps can reduce the body’s stress response and improve the gastrointestinal environment,with good safety.