全氟化碳类纳米分子成像探针增强乏氧肿瘤疗效研究进展

Progress of Perfluorocarbon Nanomolecular Imaging Probe in Enhancing the Efficacy of Hypoxic Tumor

肿瘤乏氧微环境的存在明显增加了肿瘤对临床常用治疗方法的抵抗和肿瘤自身的恶性程度。基于全氟化碳的纳米分子成像探针可携带、递送和释放氧气,具备可改善肿瘤乏氧的独特优势;另外,还能够进行19F-MR分子成像以监测和评价氧改善程度。其他协同当前多种临床常用以及全新的癌症诊疗方法方面都具有巨大的研究价值和应用潜力。全文对目前已研发的全氟化碳类纳米分子成像探针进行评述,讨论现有全氟化碳类纳米分子成像探针在缓解肿瘤乏氧微环境、协同不同癌症治疗方法方面研究进展。

Hypoxic micro-environment significantly increases the malignancy of tumor and its resistance to clinical treatment.The perfluorocarbon-based nano-molecular imaging probe delivers and releases oxygen,with the unique advantage of improving the tumor hypoxia.In addition,(19)F magnetic resonance(MR)molecular imaging is able to monitor and evaluate oxygen improvement;therefore,its diagnostic value and therapeutic application can be integrated clinically.This article reviews the current research progress of perfluorocarbon nano-molecular imaging probe,and its effect in mitigation of tumor hypoxia environment to enhance the efficacy of various tumor therapies.