Wnt信号通路在急性T淋巴细胞白血病中作用机制的研究进展

Progress of the mechanism of Wnt signaling pathway in T-cell acute lymphoblastic leukemia

急性T淋巴细胞白血病(T-ALL)起源于前体T细胞恶性转变和克隆性增殖。T-ALL的发生通常与基因突变和(或)染色体易位有关,从而导致T细胞发育中的T细胞生存、增殖和祖细胞分化的通路发生改变。研究表明,Wnt信号通路对造血干细胞调节和正常T细胞发育至关重要,在T-ALL中也发生异常改变。文章就近年Wnt信号通路在T-ALL发展中作用机制的研究进展进行综述。

T-cell acute lymphoblastic leukemia(T-ALL)is derived from the malignant transformation and clonal proliferation of precursor T cells.T-ALL is usually associated with the genetic mutations and/or chromosomal translocation,thus causing the change of survival,proliferation and progenitor cell differentiation of T cells in T-cell development.Studies have shown that Wnt signaling pathway plays a key role in the regulation of hematopoietic stem cell and normal T-cell development,and it is also abnormally altered in T-ALL.This article reviews the research progress of the mechanism of Wnt signaling pathway in T-ALL development.