间充质干细胞来源的细胞外囊泡治疗创伤性脑损伤的研究进展

Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of traumatic brain injury

创伤性脑损伤(TBI)是导致死亡和残疾的主要原因之一。随着干细胞治疗与再生医学的发展,间充质干细胞(MSCs)移植治疗TBI改善颅脑神经功能障碍成为可能。目前研究显示,MSCs的神经保护作用之一是基于分泌多种生物活性物质,其中细胞外囊泡(EVs)起到一定的治疗作用。MSC-EVs作用机制可能与神经保护,调节免疫应答,促进血管生成,增加神经发生、保护血脑屏障有关。本文主要介绍MSC-EVs在治疗TBI中的研究进展。

Traumatic brain injury(TBI)is one of the leading causes of death and disability.With the development of stem cell therapy and regenerative medicine,it is possible for mesenchymal stem cells(MSCs)transplantation to treat TBI and improve craniocerebral neurological dysfunction.Current studies have shown that one of the neuroprotective effects of MSCs is based on the secretion of a variety of bioactive substances,in which extracellular vesicles(EVs)play a certain therapeutic role.The mechanism of MSC-EVs may be related to neuroprotection,regulating immune response,promoting angiogenesis,increasing neurogenesis and protecting the blood-brain barrier.This article mainly introduces the research progress of MSC-EVs in the treatment of TBI.