鱼源宿主防御肽生物学活性及其潜在应用

Biological Activities and Potential Applications of Host Defense Peptides from Fish

宿主防御肽(HDPs)是动物机体先天免疫系统的重要组成部分,具有分子质量小、热稳定性好和不易产生耐药性等特点。作为极具潜力的抗生素替代物,HDPs不仅具有抗细菌、抗真菌和抗病毒等生物学活性,还具有多种免疫调节功能。鱼类是HDPs的重要来源,然而除小部分鱼源HDPs被用于抗菌活性研究外,其余鱼源HDPs的潜在应用还未被深入研究。本文在查找已鉴定得到的鱼源HDPs数据的基础上,系统梳理并总结了鱼源HDPs的分类,探讨了其生物学活性、潜在功能与应用,以期为鱼源HDPs的进一步应用提供理论参考,也为新型绿色功能饲料添加剂与抗菌药物的开发提供指导。

Host defense peptides are an important part of the innate immune system of animals,which are characterized by low molecular weight,good thermal stability and less susceptible to drug resistance.As a potential substitute for antibiotics,host defense peptides not only have biological activities such as anti-bacterial,anti-fungal and antiviral,but also have a variety of immunomodulatory effects.Fish are an important source of host defense peptides.However,a small number of host defense peptides from fish have been used in the study of antimicrobial activity,and other potential applications of host defense peptides from fish have not been thoroughly investigated.On the basis of the data source of host defense peptides from fish,this article systematically arranges and summarizes the classification of the fish host defense peptides,discusses the potential functions and their biological activities and applications,so as to provide theoretical reference for the further application of fish host defense peptides,as well as guide the development of new green feed additives and antimicrobial agents.