血清PECAM-1、IGF-1水平与进展期胃癌患者临床病理特征的相关性

Correlation between serum PECAM-1,IGF-1 levels and clinicopathological features in patients with advanced gastric cancer

目的:观察血清血小板内皮细胞黏附分子-1(PECAM-1)、胰岛素样生长因子-1(IGF-1)在进展期胃癌(GC)患者中的表达情况,并分析两者与临床病理特征的关系。方法:前瞻性纳入2017年3月~2020年6月中国人民解放军第八十二集团军医院收治符合条件的85例进展期GC患者,记录患者病理特征及基线资料,检测血清PECAM-1、IGF-1水平,并分析两者与进展期GC患者临床病理特征的关系。结果:85例进展期GC患者中,肿瘤直径>5 cm 37例,临床分期Ⅳ期43例,组织低/中分化39例,病理类型为腺癌50例,淋巴结转移28例;不同肿瘤直径、组织分化程度、病理类型患者血清PECAM-1、IGF-1比较,差异无统计学意义(P>0.05);Ⅳ期及淋巴结转移患者血清PECAM-1、IGF-1水平均高于Ⅲ期及无淋巴结转移患者,差异有统计学意义(P<0.05)。血清PECAM-1、IGF-1单独及联合预测进展期GC患者临床高分期及淋巴结转移风险的曲线下面积(AUC)>0.80,均有一定预测价值。结论:血清PECAM-1、IGF-1过表达可能与进展期GC患者临床高分期、淋巴结转移密切相关,且两者用于预测患者病理分期及淋巴结转移有一定价值。

Objective:To investigate the expression of platelet endothelial cell adhesion molecule-1(PECAM-1)and insulin-like growth factor-1(IGF-1),and analyze the relationship of the two protein levels and clinicopathological features in patients with advanced gastric cancer(GC).Methods:Eighty-five eligible patients with advanced GC treated in our hospital were prospectively included from March 2017 to June 2020.All patients were maintained on their pathological features and baseline data,and underwent measurement of serum PECAM-1 and IGF-1 levels.Then the relationship between the levels of the two proteins and the clinicopathological features was analyzed in patients of advanced GC.Results:Of the 85 patients with advanced GC,tumor diameter>5cm was seen in 37.Forty-three patients were in clinical stage IV,and 39 were in low/medium differentiation.Pathological findings demonstrated that 50 patients were adenocarcinoma,and lymph node metastasis occurred in 28.The serum PECAM-1 and IGF-1 levels were not significantly different in patients with different tumor diameter,histological differentiation and pathological type(P>0.05),yet patients of stage IV and with lymph node metastasis had higher serum PECAM-1 and IGF-1 levels than those of stage III and without lymph node metastasis(P<0.05).Single detection of serum PECAM-1 or IGF-1 or combined measurement of the two proteins was certain predictive value in advance GC patients with high clinical stage and risks of lymph node metastasis(AUC>0.80).Conclusion:Over expression of PECAM-1 and IGF-1 may be closely related to high clinical stage and lymph node metastasis in patients with advanced GC,and both of the proteins have certain value in predicting the pathological stage and lymph node metastasis.