血清CEACAM1对结直肠癌诊断的临床价值分析

Analysis on the clinical value of serum CEACAM1 in the diagnosis of colorectal cancer

目的:检测血清癌胚抗原相关细胞黏附分子1(CEACAM1)在结直肠癌患者血清中的水平,探讨其在结直肠癌中的诊断价值并分析其与临床病理资料之间的关系。方法:采用ELISA法测定了50例结直肠癌患者、30例结直肠良性疾病患者和30例健康对照者血清CEACAM1水平,并进一步分析其与临床病理特征的相关性及诊断效能。结果:结直肠癌组CEACAM1血清浓度[469.1(258.1~637.5)pg/mL]较结直肠良性疾病组[246.8(206.9~311.3)pg/mL]和健康对照组[245.2(207.1~287.9)pg/mL]升高(P<0.05);Ⅲ/Ⅳ期结直肠癌患者血清CEACAM1浓度高于Ⅰ/Ⅱ期患者(P<0.01)。有淋巴结转移与远处转移的结直肠癌患者血清CEACAM1浓度均升高,差异有统计学意义(P<0.05)。ROC曲线分析表明,血清CEACAM1是筛选结直肠癌患者的一种潜在生物标志物(AUC=0.749,54.0%)。CEACAM1对结直肠癌的诊断特异度(96.7%)略高于CEA(86.7%);CEACAM1与CEA联合检测效能(AUC=0.822)和灵敏度(76.0%)略提高。结论:血清CEACAM1可能是结直肠癌的一种潜在生物标志物。与CEA联合检测可略提高结直肠癌的诊断效能并与结直肠癌的分期、转移相关。

Objective:To assess the diagnostic value of serum carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1)level in patients with colorectal cancer,and investigate its relationship with clinicopathological data.Methods:Serum CEACAM1 level was measured in 50 patients of colorectal cancer,30 patients with benign colorectal disease and 30 healthy controls using ELISA,and the correlation between CEACAM1 and clinicopathological features and diagnostic efficacy were analyzed.Results:Serum CEACAM1 concentration in the colorectal cancer group[469.1(258.1-637.5)pg/mL]was significantly higher than that in the benign colorectal disease group[246.8(206.9-311.3)pg/mL]and the healthy control group[245.2(207.1-287.9)pg/mL](P<0.05),and higher in patients with stage III/IV colorectal cancer than in those with stage I/II(P<0.01).Still,evidently increased serum CEACAM1 level was seen in colorectal cancer patients with lymph node metastasis and distant metastasis(P<0.05).ROC curve analysis showed that serum CEACAM1 was a potential biomarker for screening of colorectal cancer(AUC=0.749;54.0%).The diagnostic specificity of CEACAM1 in colorectal cancer(96.7%)was slightly higher than that of CEA(86.7%),and combined measurement of CEACAM1 and CEA can improve the detection efficiency(AUC=0.822)and sensitivity(76.0%)to a certain degree.Conclusion:Serum CEACAM1 may be a potential biomarker for colorectal cancer,and is associated with staging and metastasis of colorectal cancer.Combined detection of it with CEA can slightly improve the diagnostic efficacy.