槐杞黄颗粒联合阿奇霉素和布地奈德雾化吸入治疗支原体肺炎疗效分析

Effect of Huaiqihuang granule plus azithromycin and budesonide on fractional exhaled nitric oxide and immune function in children with Mycoplasma pneumonia

目的:探讨槐杞黄颗粒联合阿奇霉素和布地奈德雾化吸入治疗支原体肺炎的临床疗效。方法:选取2017年9月~2019年9月入住邢台市人民医院的200例支原体肺炎患儿,对照组(100例)采用阿奇霉素联合布地奈德雾化吸入治疗,治疗组(100例)在此基础上再给予槐杞黄颗粒进行治疗,检测治疗2周后患儿血清超敏C反应蛋白(hs-CRP)、可溶性B7-H3(sB7-H3)、呼出气一氧化氮(FENO)和T细胞亚群(CD3^(+)、CD4^(+)和CD8^(+))水平。结果:治疗组临床疗效优于对照组;治疗后两组患者血清hs-CRP、sB7-H3降低而FENO升高,且治疗组的hs-CRP、sB7-H3和CD8^(+)含量均低于对照组而CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)和FENO则高于对照组。结论:槐杞黄颗粒联合阿奇霉素和布地奈德雾化吸入治疗支原体肺炎疗效显著,值得临床推广使用。

Objective:To observe the clinical effect of Huaiqihuang granule combined with azithromycin and budesonide inhalation in the treatment of mycoplasma pneumonia in children.Methods:200 children with Mycoplasma pneumonia treated in our hospital between September of 2017 and 2019 were included,and divided into control group and treatment group(n=100 for each group).Patients in control group received aerosol inhalation using azithromycin and budesonide,on which basis the children in the treatment group were given additional Huaiqihuang granule.All patients underwent measuring serum levels of high-sensitivity C-reactive protein(hsCRP),soluble B7-H3(sB7-h3),fractional exhaled nitric oxide(FENO)and T cell subsets(CD3^(+),CD4^(+)and CD8^(+))before therapy and 2 weeks following medication.Results:The clinical efficacy of the treatment group was significantly better than that of the control group.Significantly decreased serum levels of hsCRP and sB7-h3 and increased fractional exhaled nitric oxide(FENO)level were seen in both groups.And the levels of hsCRP,sB7-h3 and CD8^(+)were evidently lower in the treatment group than in the control group,whereas higher serum CD3^(+),CD4^(+),CD4^(+)/CD8^(+) and FENO levels were noted in the treatment group.Conclusion:Huaiqihuang granule combined with inhalation of azithromycin and budesonide can produce better clinical efficacy in treatment of Mycoplasma pneumonia,which is worthy of clinical recommendation.