摘要
Hematopoietic stem cells(HSCs)replenish all lineages of blood cells throughout the lifespan.During aging,the repopulation capacity of HSCs declined,and aged HSCs display a tendency for myeloid differentiation.Several intrinsic and extrinsic factors have been identified to promote HSCs aging.In this review,we focus on the contribution of aging-associated inflammation in provoking HSCs aging and discuss the future research direction of inflammation and HSC aging.
基金
This work was supported by grant numbers 2018YFA0800200,2017YFA0104000,Z181100001818005 and 91849106 to J.W
W.,from the National KeyR&D Program of China or the Beijing Municipal Science&Technology Commission and the National Natural Science Foundation of China.
