摘要
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is one of the most effective methods in the treatment of leukemia and other malignant hematological diseases.However,the occurrence of acute graft-versus-host disease(aGVHD)seriously impairs the survival and prognosis of patients,and the mortality rate of aGVHD is about 10%.^(1) During the development of aGVHD,the initial step consists of injury to the host tissues caused by conditioning regimen.
基金
This work has been supported by National Key Research and Development Program(2019YFC0840604)
National Natural Science Foundation of China(81730003).
