L-4F对小鼠胰腺癌的抑制作用

Inhibitory effect of L-4F on pancreatic cancer in mice

目的探讨载脂蛋白A-I模拟肽L-4F对小鼠胰腺癌的抑制作用。方法用胰腺癌细胞系H7构建小鼠胰腺癌模型,将胰腺癌原位荷瘤小鼠随机分为L-4F组与Sc-4F组,每组8只,L-4F组接受L-4F(10 mg/kg)腹腔注射治疗,Sc-4F组接受无功能对照Sc-4F(10 mg/kg)腹腔注射治疗。观察两组小鼠的肿瘤体积,比较两组小鼠的肿瘤重量及肿瘤组织中血管生成及炎性反应情况。结果与Sc-4F组小鼠的肿瘤重量比较,L-4F组小鼠的肿瘤重量明显下降,差异有统计学意义(P<0.05)。Sc-4F组小鼠肿瘤组织中有大量血管生成、炎症细胞大量浸润,与其相比,L-4F组小鼠肿瘤组织中的血管数量及炎症细胞数量大量减少。结论L-4F对小鼠胰腺癌的生长具有一定的抑制作用。

Objective To explore the inhibitory effect of apolipoprotein A-I mimic peptide L-4F on pancreatic cancer in mice.Methods Pancreatic cancer cell line H7 was used to construct mice pancreatic cancer model.The pancreatic cancer in situ tumor bearing mice were randomly divided into L-4F group and Sc-4F group,with 8 mice in each group.L-4F group received intraperitoneal injection of L-4F(10 mg/kg),and Sc-4F group received intraperitoneal injection of nonfunctional control Sc-4F(10 mg/kg).The tumor volume of the two groups of mice was observed,and the tumor mass,angiogenesis and inflammatory response of the two groups of mice were compared.Results Compared with the tumor mass of mice in the Sc-4F group,the tumor mass of mice in the L-4F group decreased significantly,and the difference was statistically significant(P<0.05).There were a large number of angiogenesis and inflammatory cells infiltration in the tumor tissue of the Sc-4F group mice.Compared with Sc-4F group,the number of blood vessels and the number of inflammatory cells in the tumor tissue of the L-4F group were greatly reduced.Conclusion L-4F has a certain inhibitory effect on the growth of pancreatic cancer in mice.