DON生物合成的亚细胞定位和精准外排研究进展

Subcellular Localization and Cellular Machinery Required for Deoxynivalenol Assembly:Updates and New Insights

单端孢霉烯B族毒素脱氧雪腐镰刀烯醇(deoxinivalenol,DON)是产毒镰刀菌在侵染小麦等作物过程中的一类重要的致病因子,可以帮助产毒镰刀菌在麦穗间扩展。DON会抑制蛋白质合成,对动物、微生物和寄主具有毒性(cytotoxicity and phytotoxicity),然而产毒镰刀菌自身借助何种保护机制免受DON毒害目前研究甚少。DON毒害机制的研究对于镰刀菌毒素的持续防控和粮食安全、人民生命健康保障具有重要意义。综述了产毒镰刀菌DON合成解毒机制的最新研究进展,主要包括DON合成的亚细胞定位、合成基因簇内的外排蛋白和解毒基因作用方式,以期为有针对性地破解其解毒机制,设计研发高效靶向控毒技术的相关研究提供参考。

Deoxinivalenol(DON),the type-B trichothecene,has been proven as the important virulence factor for the aggressiveness of Fusarium graminearum in wheat head.As the protein synthesis inhibitor,DON has certain levels of cytotoxicity or phytotoxicity to mammal cells,microorganisms and plant cells.However,the protective mechanism of Fusarium spp.to DON is larely unknown.Better understanding of their detoxification mechanisms is of great importance.This review highlighted the self-protection mechanisms of Fusarium spp.to DON,specifically including the subcellular compartmentation of biosynthesis,delivery and timing orchestrated through cellular trafficking manners,which was expected to help understand its detoxification mechanism and provide targets for designing targeted control strategy,and protect food safety and health of both humans and livestock.