摘要
冠状动脉粥样硬化性心脏病(CHD)是威胁人类生命健康的常见疾病,其中血脂代谢异常是CHD最主要的危险因素,与冠状动脉粥样硬化的发生和发展密切相关。血浆载脂蛋白B(ApoB)是血浆脂蛋白的主要成分之一,通过介导脂蛋白的滞留,诱导免疫炎症和细胞凋亡等参与动脉粥样硬化的发生和发展。研究表明血浆ApoB是CHD的重要危险因素,现就血浆ApoB的分子结构、代谢途径、致动脉粥样硬化机制以及在CHD的临床应用价值综述如下。
Coronary atherosclerotic heart disease(CHD)is a common disease that threatens human life and health.Among them,dyslipidemia is the most important risk factor for CHD,which is closely related to the occurrence and development of coronary atherosclerosis.Plasma apolipoprotein B(ApoB)is one of the main components of plasma lipoprotein,which participates in the occurrence and development of atherosclerosis by mediating lipoprotein retention,inducing immune inflammation and cell apoptosis.Studies have shown that plasma ApoB is an important risk factor for CHD.In this paper,the molecular structure,metabolic pathway,atherogenic mechanism and clinical application value of plasma ApoB in CHD are reviewed as follows.
作者
黄志斐
张秀兰
HUANG Zhifei;ZHANG Xiulan(Shanxi Medical University,Taiyuan 030001,Shanxi,China;The Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China)
出处
《心血管病学进展》
2021年第9期825-828,共4页
Advances in Cardiovascular Diseases
