TLR2、TLR4和NOD2/CARD15基因多态性与溃疡性结肠炎相关性的meta分析

Association Between TLR2,TLR4 and NOD2/CARD15 Gene Polymorphisms and Ulcerative Colitis:A Meta-analysis

背景:近年我国溃疡性结肠炎(UC)的患病率明显增高,Toll样受体2(TLR2)、TLR4和NOD2/CARD15基因多态性与UC的发生、发展可能密切相关。目的:探讨TLR2、TLR4和NOD2/CARD15基因多态性对UC发生的影响。方法:计算机检索PubMed、中国生物医学文献、中国知网、万方数据库、重庆维普等数据库中所有TLR2、TLR4和NOD2/CARD15基因多态性与UC相关性的研究。按照纳入与排除标准筛选文献、评价质量并提取数据,采用RevMan 5.3软件进行meta分析。结果:共纳入15项研究。Meta分析结果显示,TLR2 Arg753Gln基因多态性与UC发生风险无关(P>0.05)。除隐性模型外,TLR4 Asp299Gly基因多态性可显著增加UC的发生风险(P<0.05),TLR4 Thr399Ile基因超显性模型可导致UC风险增加(P<0.05),但显性模型和隐性模型与UC无关(P>0.05)。NOD2/CARD15(Arg702Trp、Gly908Arg、Leu1007fsinsC)基因多态性均与UC无关(P>0.05)。结论:NOD2/CARD15(Arg702Trp、Gly908Arg、Leu1007fsinsC)、TLR2(Arg753Gln)与UC发生风险无关,TLR4(Asp299Gly、Thr399Ile)可增加UC的发生风险。

Background:The prevalence rate of ulcerative colitis(UC)in China has increased significantly in recent years,and Toll-like receptor 2(TLR2),TLR4 and NOD2/CARD15 may be closely related to the development of UC.Aims:To explore the influence of TLR2,TLR4 and NOD2/CARD15 gene polymorphisms on the pathogenesis of UC.Methods:Studies on correlation of TLR2,TLR4 and NOD2/CARD15 gene polymorphisms with UC were retrieved from PubMed,CBM,CNKI,Wanfang,VIP databases.Literatures were enrolled according to the inclusion and exclusion criteria,and the quality was evaluated and data were extracted.RevMan 5.3 software was used to conducted meta-analysis.Results:Fifteen eligible articles were included.Meta-analysis showed that TLR2 Arg753Gln gene polymorphism was not associated with risk of UC(P>0.05).Except the recessive model,TLR4 Asp299Gly gene polymorphism could increase the risk of UC(P<0.05).The overdominant model of TLR4 Thr399Ile gene could increase the risk of UC(P<0.05),but not the dominant model and recessive model(P>0.05).No significant association between NOD2/CARD15(Arg702Trp,Gly908Arg and Leu1007fsinsC)gene polymorphism and UC was found(P>0.05).Conclusions:Existing evidence shows that TLR4(Asp299Gly,Thr399Ile)gene polymorphisms are associated with an increased risk of UC,however,NOD2/CARD15(Arg702Trp,Gly908Arg and Leu1007fsinsC)and TLR2(Arg753Gln)gene polymorphisms are not associated with UC.