基孔肯雅病毒小鼠感染模型研究进展

Research progress in the mouse infection model for Chikungunya virus

基孔肯雅病毒(Chikungunya virus,CHIKV)感染引发的基孔肯雅热是一种主要经伊蚊叮咬而传播的虫媒传染病,近些年已在100多个国家流行或暴发,成为严重威胁全球公共卫生安全的虫媒病毒性传染病。CHIKV感染后可以引起急性发热、皮疹、肌肉疼痛以及慢性关节炎、腱鞘炎等临床症状,严重者可发生病毒性脑炎。小鼠模型作为CHIKV最常用的动物感染模型,在病毒感染机理、宿主抗感染免疫机制以及相关疫苗或药物研发等方面应用广泛。本文拟就国内外关于基孔肯雅病毒小鼠感染模型的最新研究进展作一综述。

Chikungunya fever is a reemerging and arthropod-borne viral infection caused by Chikungunya virus(CHIKV),which is mainly transmitted by Aedes ssp.mosquitoes.It is found in more than 100 countries worldwide and is a serious public health concern.Typical clinical symptoms of CHIKV infection in humans are acute fever,skin rash,severe joint and muscle pain,chronic arthritis,and prolonged tenosynovitis.The virus may invade the brain and cause death.Mouse models are commonly used,and are powerful experimental animal models for studying CHIKV infection pathogenesis and host-microbe interaction factors,and exploring and evaluating the efficacy and safety of therapeutics and vaccines against CHIKV.This review provides an overview of major recent advances in the understanding of chikungunya from studies in the mouse model.