粪菌移植对慢性肠炎患者预后的影响

Impact of fecal bacteria transplantation on the prognosis of patients with chronic enteritis

目的初步分析粪菌移植对慢性肠炎患者预后的影响。方法以我院2017年1月至2019年6月收治的100例慢性肠炎患者为研究对象,采用简单随机抽样法分为观察组与对照组各50例。移植粪菌均来自于健康志愿者。移植方法为以50 mL/h注入粪汁50 mL,间隔2 h,再次以50 mL/h注入粪汁50 mL。对照组患者共移植粪便50 g,观察组患者共移植粪便100 g。对比两组患者腹泻频率、观察指标及血清炎症因子以及肠道菌群改善情况。结果治疗第1个月两组患者腹泻频率差异无统计学意义(P>0.05),但随着治疗时间的延长患者腹泻频率逐渐降低,且观察组低于对照组(均P<0.05)。治疗前两组患者家属疾病认知程度、主观幸福度及家属焦虑抑郁评分差异无统计学意义(均P>0.05)。治疗6个月后,两组患者主观幸福度评分、患者家属疾病认知程度均提升,家属焦虑抑郁量表评分均下降,且观察组优于对照组(均P<0.05)。治疗前,两组患者TNF-α与IL-6水平差异无统计学意义(均P>0.05)。治疗后,试验组患者TNF-α与IL-6水平均低于对照组(均P<0.05)。治疗后两组患者肠镜检查结果以及肠道菌群检查结果均得到改善。结论粪菌移植能有效改善慢性肠炎患者的临床症状,值得临床推广。

Objective To analyze the impact of fecal bacteria transplantation on the prognosis of patients with chronic enteritis. Methods A total of 100 patients with chronic enteritis treated in our hospital from January 2017 to June 2019 were selected as the subjects, and randomly divided into the observation group or control group(n=50). The transplanted fecal bacteria were from healthy volunteers. 50 mL of fecal juice were injected at 50 mL/h twice with an interval of 2 hours. Patients in control group were injected feces 50 g while the observation group were injected feces 100 g. The frequency of diarrhea, observation indicators, serum inflammatory factors and improvement of intestinal flora were compared between the two groups. Results There was no significant difference in the diarrhea rate between the two groups during the first month of intervention(P>0.05). The diarrhea rate decreased with the extension of the intervention time, which was lower in the observation group than that in the control group(all P<0.05). There were no significant differences in patients′ family disease awareness, GWB scale, patients′ family anxiety and depression scores before intervention(all P>0.05). Six months after intervention, the GWB scale scores and patients′ family disease awareness in both groups increased, while the patients′ family anxiety and depression scale scores decreased, with the observation group superior to the control group(all P<0.05). Before treatment, there were no significant differences in the levels of TNF-α and IL-6 between two groups, while after treatment, the levels of TNF-α and IL-6 in the observation group were lower than those in the control group(all P<0.05). After treatment, the results of colonoscopy and intestinal flora detection of the two groups were improved. Conclusion Fecal bacteria transplantation can effectively improve the clinical symptoms of patients with chronic enteritis, which is worthy of clinical promotion.