PET/CT医用68Ge-68Ga模体的制备工艺及均匀性分析

Preparation Process and Uniformity Analysis of a PET/CT Medical ^(68)Ge-^(68)Ga Phantom

68Ge-68Ga模体主要用于PET/CT图像均匀性的调节以及SUV值的校正。为了实现该模体的国产化,本文采用改性后的环氧树脂为填充基质,通过载体溶液模拟68Ge-68Ga放射性溶液。将载体溶液、树脂以及固化剂混匀后的物料浇注在高密度聚乙烯(HDPE)外壳中,然后在物料完全固化后制成质地坚硬、色泽通透、无气泡的非放模体。使用电感耦合等离子体发射光谱仪(ICP-OES)检测该模体中Ge、Ga元素浓度,均匀性分析结果显示该模体中Ge、Ga浓度分布差异性不显著,相对标准偏差分别为2.20%、3.65%,与国外同类产品水平相当。表明文中所述工艺可用于68Ge-68Ga模体的制备。

68Ge-68Ga phantoms are mainly used in PET/CT image uniformity adjustment and SUV value correction.In order to produce a 68Ge-68Ga phantom,an epoxy resin modified by poly sulfide rubber was used as the substrate and the carrier solution of 68Ge-68Ga was used to simulate 68Ge-68Ga radioactive solution.The homogeneous mixture of carrier solution,epoxy resin,and curing agent was filled in a shell of high density polyethylene(HDPE).After the mixture was solidified completely,a non-radioactive phantom with hard texture,color transparent and non-bubble was prepared.Inductively coupled plasma-optical emission spectrometer(ICP-OES)was used to detect the concentration of Ge and Ga elements in the phantom.The results of uniformity analysis showed that there was no significant difference in the concentration distribution of Ge and Ga in the phantom,and the relative standard deviations were 2.20% and 3.65%,respectively,which were equivalent to similar imported products.It was indicated that the process described in this paper can be used for the preparation of 68Ge-68Ga phantom.