摘要
The study of plant diseases is almost as old as agriculture itself. Advancements in molecular biology havegiven us much more insight into the plant immune system and how it detects the many pathogens plantsmay encounter. Members of the primary family of plant resistance (R) proteins, NLRs, contain three distinctdomains, and appear to use several different mechanisms to recognize pathogen effectors and trigger immunity. Understanding the molecular process of NLR recognition and activation has been greatly aided byadvancements in structural studies, with ZAR1 recently becoming the first full-length NLR to be visualized.Genetic and biochemical analysis identified many critical components for NLR activation and homeostasiscontrol. The increased study of helper NLRs has also provided insights into the downstream signaling pathways of NLRs. This review summarizes the progress in the last decades on plant NLR research, focusing onthe mechanistic understanding that has been achieved.
基金
The research of the laboratory is supported by funds from the NSERC-CREATE PRoTECT program,NSERC-Discovery,CFI
the Dewar Cooper memorial funds from the University of British Columbia.S.v.W.is partially funded through the UBC Michael Smith Fellowship and NSERC-CGSM awards
L.T.is partly supported by a CSC scholarship.
