母羊妊娠毒血症发病分子机制研究进展

Research progress on molecular mechanism of pregnancy toxemia in ewes

母羊妊娠毒血症是一种多发于妊娠后期怀多羔母羊的代谢性疾病,可造成母羊早产或流产等,其最大的危害在于造成妊娠母羊的高死亡率。近年来,因育种上追求高产多胎,导致羊妊娠毒血症频发。了解该病的发病机制尤其分子机制有助于预防该病的发生,减少牧场损失。因此,文章对与母羊妊娠毒血症发生相关的促进绵羊多胎的基因骨形态蛋白IB受体(BMPR-IB),以及在羊肝脂代谢过程中发挥重要作用的基因如二酰基甘油酯α(DAGLA)、脂质代谢关键酶基因、三酰甘油合成(TGS)相关基因、3-羟基-3-甲基戊二酰辅酶A合成酶(HMGCS)、腺苷酸激活的蛋白激酶(AMPK)和血管生成素样蛋白(ANGPTLs)等进行综述,并梳理了各基因的相互关系,以期为研究本病的发病机制提供参考。

Pregnancy toxemia in ewes is a metabolic disease that frequently occurs in ewes with multiple lambs in the late pregnancy, which can cause premature delivery or miscarriage of the ewes, and its greatest harm is the high mortality of pregnant ewes. In recent years, meat breeding ewes with high yield and multiple births have become the first breeding target, leading to frequent and high incidences of pregnancy toxemia in sheep. Understanding the pathogenesis of the disease, especially the molecular mechanism, helps prevent the occurrence of the disease and reduce the loss of pasture. Hence, this article reviewed the bone morphoprotein IB receptor gene(BMPR-IB),which is related to the occurrence of this disease and promotes multiple births in sheep, as well as the genes play an important role in the process of sheep liver lipid metabolism, such as diacylglyceride alpha(DAGLA),key lipid metabolism enzyme genes, triglyceride synthesis(TGS) related genes, 3-hydroxy-3-methylglutaryl-CoA synthase(HMGCS),adenylate-activated protein kinase(AMPK) and angiopoietin-like proteins(ANGPTLs). The interrelationship of each gene was sorted out, in order to provide reference for the study of the pathogenesis of this disease.