艾灸结合桂附萸和汤对过敏性痤疮患者特禀质转化积分及血清总IgE和血中嗜酸性粒细胞的影响

Effect of moxibustion combined with Guifu Yuhe decoction on the conversion score of idiopathic constitution,serum total lgE and blood EOS in the patients with allergic acne

目的:观察艾灸结合桂附萸和汤对过敏性痤疮患者的疗效及对免疫功能的影响。方法:60例过敏性痤疮患者随机分为观察组(30例)、对照组(30例),30例健康职工为健康组。对照组给予桂附萸和汤口服治疗,观察组在对照组基础上艾灸大椎、神阙,治疗时间均为8周。比较治疗前后两组患者血清总免疫球蛋白E(IgE)及血中嗜酸性粒细胞(EOS)、CD4^(+)T细胞、CD8^(+)T细胞,特禀质转化积分,症状评分,并观察两组临床疗效。结果:治疗前与健康组比较,两组过敏性痤疮患者IgE及EOS、CD4^(+)T细胞、CD8^(+)T细胞含量升高(P<0.01,P<0.05),CD4^(+)T/CD8^(+)T下降(P<0.05)。治疗后,与本组治疗前比较,两组患者IgE及EOS、CD4^(+)T细胞、CD8^(+)T细胞含量下降(P<0.05),CD4^(+)T/CD8^(+)T升高(P<0.05);观察组IgE及EOS、CD4^(+)T细胞、CD8^(+)T细胞改变较对照组更明显(P<0.05)。两组特禀质转化积分、症状评分治疗后均下降(P<0.05),且观察组低于对照组(P<0.05)。观察组总有效率为96.7%(29/30),对照组总有效率为73.3%(22/30),观察组高于对照组(P<0.05)。结论:艾灸结合桂附萸和汤对过敏性痤疮患者免疫功能、特禀体质均明显改善,其治疗过敏性痤疮机制可能与纠正特禀体质、改善淋巴细胞亚群功能紊乱及抑制变态反应有关。

Objective To observe the therapeutic effect of moxibustion combined with Guifu Yuhe decoction on allergic acne and the influence on immunologic function in the patients.Methods A total of 60 patients with allergic acne were rando-mized into an observation group(30 cases)and a control group(30 cases).Thirty healthy employees were in the healthy group.In the control group,Guifu Yuhe decoction was prescribed for oral administration,while in the observation group,on the base of the treatment as the control group,moxibustion was exerted at Dazhui(GV14)and Shenque(GV8).The treatment duration was 8 weeks.Before and after treatment,serum IgE,blood EOS,CD4^(+)T cell,CD8^(+)T cell and CD4^(+)T/CD8^(+)T,as well as the conversion score of idiopathic constitution and the symptom score were compared in the patients of two groups.The clinical therapeutic effect was observed in the two groups.Results Before treatment,compared with the healthy group,IgE and EOS,CD4^(+)T cell and CD8^(+)T cell all increased(P<0.05),and CD4^(+)T/CD8^(+)T decreased in the two groups(P<0.05).After treatment,IgE,EOS and CD4^(+)T cell and CD8^(+)T cell decreased(P<0.05),and CD4^(+)T/CD8^(+)T increased(P<0.05)in the intra-group comparison in the patients.The changes of IgE,EOS,CD4^(+)T cell and CD8^(+)T cell in the observation group were more larger than those in the control group(P<0.05).After treatment,the conversion score of body constitution and symptom score all decreased in either group(P<0.05)and the scores in the observation group were lower than those of the control group(P<0.05).The total effective rate of the observation group(29/30,96.7%)was higher than that of the control group(22/30,73.3%,P<0.05).Conclusion Moxibustion combined with Guifu Yuhe decoction can significantly improve immune function and body constitution of the patients with allergic acne,which may be related to rectifying idiopathic constitution,improving in lymphocyte subsets dysfunction and inhibiting allergic reaction.