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Recent progress on betulinic acid and its derivatives as antitumor agents:a mini review 被引量:1

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摘要 Natural products are one of the important sources for the discovery of new drugs.Betulinic acid(BA),a pentacyclic triterpenoid widely distributed in the plant kingdom,exhibits powerful biological effects,including antitumor activity against various types of cancer cells.A considerable number of BA derivatives have been designed and prepared to remove their disadvantages,such as poor water solubility and low bioavailability.This review summarizes the current studies of the structural diversity of antitumor BA derivatives within the last five years,which provides prospects for further research on the structural modification of betulinic acid.
出处 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2021年第9期641-647,共7页 中国天然药物(英文版)
基金 supported by the National Natural Science Foundation of China(Nos.20472054,30772641,30973613,21142010 and 81473087)。
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