2001—2018年广东省深圳市结直肠癌发病现状和趋势分析

The Incidence and Trend of Colorectal Cancer in Shenzhen City from 2001 to 2018

[目的]探讨2001—2018年深圳市户籍居民结直肠癌发病趋势。[方法]根据深圳市2001—2018年肿瘤登记发病数据以及相应人口数据,分别计算结直肠癌的粗发病率、年龄别发病率、标化发病率(中国人口标化率和世界人口标化率)、累计发病率(0~74岁)、截缩发病率(35~64岁)。运用年度变化百分比(APC)对2001—2018年期间深圳市结直肠癌的发病变化趋势进行描述。[结果]深圳市户籍居民2001—2018年间结直肠癌新发病例共9 130例,粗发病率19.37/10万,中标率27.17/10万,世标率26.80/10万,累计发病率(0~74岁)为3.19%,截缩发病率(35~64岁)为39.68/10万。男性发病率高于女性,男女发病性别比为1.43∶1。从时间趋势看,结直肠癌发病率呈显著上升趋势,世标率从2001年的22.87/10万升至2018年的29.99/10万,APC为1.86%(P<0.05)。发病率随年龄增长而增高,从50岁开始快速上升,于80~84岁时达到发病高峰。分发病部位看,结肠癌发病率高于直肠癌;2001—2018年间结肠癌和直肠癌的粗发病率呈持续增长态势,APC分别为3.99%、1.69%(P均<0.05)。[结论]深圳市2001—2018年间结直肠癌发病呈持续增长趋势,应积极探索结直肠癌发病相关危险因素,加强早期筛查和综合干预防控研究,以期降低居民结直肠癌发病风险。

[Purpose] To analyze the incidence and trend of colorectal cancer in Shenzhen City from 2001 to 2018. [Methods] The colorectal cancer incidence data were collected from the Shenzhen Cancer Registry. Crude incidence, age-specific incidence, age-standardized rate by Chinese standard population in 2000 and Segi’s world population(ASR China and ASR world),cumulative inciden rate(0~74 years), truncated inciden rate(35 ~64 years). The annual percentage change(APC) was calculated to estimate trends of colorectal cancer. [Results] From 2001 to 2018, the total new cases of colorectal cancer in Shenzhen City were 9 130. The crude incidence was 19.37/10^(5), with ASR China of 27.17/10^(5) and ASR world of 26.80/10^(5). The cumulative rate(0~74 years) was 3.19%, and truncated rate(35~64 years) was 38.68/105. The incidence in male was significantly higher than that in female, with a sex ratio of 1.43∶1. From 2001 to 2018, the ASR world of colorectal cancer increased from 22.87/105 to 29.99/105, APC was 1.86%(P<0.05). The incidence of colorectal cancer increased with age. There was a substantial increase of the incidence after 50 years old, and the peak age of onset was at the age group of 80~84 years old. From 2001 to2018, the incidence of colon cancer was higher than that of rectal cancer and the incidence of colon and rectal cancer both had a sustainable growth, the APC was 3.99%, 1.69%(both P<0.05),respectively. [Conclusion] The incidence of colorectal cancer continuously increased from 2001 to2018 in Shenzhen City. Comprehensive study on prevention and screening should be promoted to reduce the incidence of colorectal cancer.