RISUG男性避孕针研究进展

Research progress of reversible inhibition of sperm under guidance male contraceptive needle

自1984年印度医学家报道“在指导下对精子的可逆性抑制”(reversible inhibition of sperm under guidance,RISUG)在男性避孕节育中有良好效果,并被宣布作为可以解放女性避孕痛苦的男性避孕药以来,国际上对RISUG的研究也有近40年时间。然而不同学者报道其研究结果差异甚大,部分学者报道该药效果不明显,部分报道其不良反应较大而无法深入研究。因此,该药物的有效性和安全性一直以来成为各家争论的焦点,其临床进展也缓慢不前,除药物效果值得推敲,其本身的安全性亦尚有待于进一步探讨和分析。本文就RISUG男性避孕针的研究背景、作用机理、实验基础、研究方法(包括给药方式、给药剂量、起效时间、作用效果、逆转方式、安全性等),以及所面临的问题和发展前景等方面作一综述。

Since 1984,Indian medical experts reported that reversible inhibition of sperm under guidance(RISUG)had a good effect in male contraception,and was announced as a male contraceptive which could relieve female contraceptive pain,the international research on RISUG male contraceptive had been done nearly for 40 years.However,different studies had reported that the results were very different.Some scholars reported that the effect of the drug was not obvious,and some scholars reported that the side effects of the drug were too serious to be studied in depth.Therefore,the effectiveness and safety of the drug had always been the focus of debate,so its clinical progress was slow.In addition to the effect of the drug,its safety also needed to be further explored and analyzed.In this paper,the research background,action mechanism,experimental basis,research methods(including administration mode,administration and dose,onset time,action and effect,reversal mode and effect,safety evaluation,etc.),as well as the problems and development prospects of RISUG male contraceptive needle were reviewed.