The value of PIVKA-Ⅱversus AFP for the diagnosis and detection of postoperative changes in hepatocellular carcinoma

Objective:To explore the diagnostic value of abnormal prothrombinⅡ(PIVKA-Ⅱ)and alpha-fetoprotein(AFP)in primary hepatocellular carcinoma(HCC).Methods:From 20180.01 to 2020.01,there were 158 patients with primary liver cancer caused by chronic hepatitis B(male 116,women 42)and 62 patients with chronic hepatitis B(male 34,female 28).The levels of serum PIVKA-Ⅱand AFP were measured,and the results were statistically analyzed.Results:The value of PIVKA-Ⅱin liver cancer group was distinctly higher than that in chronic viral hepatitis B group,the difference is statistically significant(P<0.05).So does the value of AFP.Draw the subject working characteristic curve(ROC curve),the area under the curve of AFP and PIVKA-Ⅱis 0.799 and 0.836,and that of the combination of AFP and PIVKA-Ⅱis 0.854,the sensitivity is 57.6%,68.4%,72.2%,respectively,the specificity is93.5%,98.4%,96.8%,respectively.After operation or interventional therapy,the value of PIVKA-Ⅱin liver cancer group was clearly lower than that before treatment,and the difference was statistically significant.Conclusion:In the diagnostic value of primary liver cancer,PIVKA-Ⅱcombined with AFP is higher than PIVKA-Ⅱ,while AFP has the lowest benefit.We also find that PIVKA-Ⅱhas higher disease monitoring value than AFP.