摘要
The public health importance of nutritional epidemiology research is discussed,along withmethodological challenges to obtaining reliable information on dietary approaches to chronicdisease prevention.Measurement issues in assessing dietary intake need to be addressed toobtain reliable disease association information.Self-reported dietary data typically incorporatemajor random and systematic biases.Intake biomarkers offer potential for more reliable analyses,but biomarkers have been established only for a few dietary variables,and these may be tooexpensive to apply to all participants in large epidemiologic cohorts.A possible way forwardinvolves additional nutritional biomarker development using high-dimensional metabolomicprofiling,using blood and urine specimens,in conjunction withfurther development of statisticalapproaches for accommodating measurement error with failure time response data.Statisticianshave the opportunity to contribute greatly to worldwide public health through the development of statistical methods to address these nutritional epidemiology research challenges,asis elaborated in this contribution.
基金
This manuscript was written with partial support from National Institutes of Health grants R01 CA210921,R01 CA119171 and P30 CA015704.
