小剂量阿司匹林辅助治疗早发型子痫前期患者的效果及对不良妊娠结局发生率的影响

Effect of Low-dose Aspirin in the Adjuvant Treatment of Early-onset Preeclampsia and Its influence on the Incidence of Adverse Pregnancy Outcomes

目的:探讨小剂量阿司匹林辅助治疗早发型子痫前期患者的效果及对不良妊娠结局发生率的影响。方法:将某院2018年2月~2019年2月期间57例子痫前期患者分组,按照随机数字表法分为对照组28例和观察组29例,对照组给予硫酸镁治疗,观察组给予硫酸镁和小剂量阿司匹林联合治疗,观察两组患者治疗效果、微炎症状态水平、凝血功能指标以及不良妊娠结局。结果:观察组总有效率为93.10%高于对照组的67.86%(P<0.05);观察组胎盘组织中TXA2、TNF-α、IL-6、COX-2水平明显低于对照组(P<0.05);观察组PT升高且高于对照组,APTT和Fib降低且低于对照组(P<0.05),对照组PT升高、APTT和Fib降低与治疗前比较P>0.05;观察组不良妊娠结局发生率为17.24%低于对照组的46.43%(P<0.05)。结论:小剂量阿司匹林辅助治疗早发型子痫前期患者可显著提高治疗效果,降低微炎症状态水平,改善凝血功能以及不良妊娠结局。

Objective:To investigate the effect of low-dose aspirin in the adjuvant treatment of early-onset preeclampsia and its influence on the incidence of adverse pregnancy outcomes.Methods:57 cases of preeclampsia in a hospital from February 2018 to February 2019 were divided into control group(28 cases,magnesium sulfate)and observation group(29 cases,magnesium sulfate combined with low-dose aspirin)according to the random number table method.The treatment effect,microinflammatory state,coagulation function index and adverse pregnancy outcome of the two groups were observed.Results:The total effective rate of the observation group was 93.10%,which was higher than 67.86%of the control group(P<0.05).The levels of TXA2,TNF-α,IL-6 and COX-2 in the placental tissue of the observation group were significantly lower than those of the control group(P<0.05);PT in the observation group was increased and higher than that in the control group,APTT and Fib were decreased and lower than those in the control group(P<0.05).The PT was increased in the control group,and APTT and Fib were decreased in the control group were increased,with no significant difference compared with those before treatment(P>0.05).The incidence of adverse pregnancy outcomes in the observation group was 17.24%,which was lower than 46.43%in the control group(P<0.05).Conclusion:Low-dose aspirin in the adjuvant treatment of early-onset preeclampsia can significantly improve the therapeutic effect,reduce the level of microinflammation,and improve coagulation function and adverse pregnancy outcomes.