长链非编码RNA及环状RNA在胆管癌中的研究进展

Progress of long non-coding RNA and circular RNA in cholangiocarcinoma

胆管癌起病隐匿且缺乏早期诊断标志物,大多数患者在确诊时已处于疾病晚期。目前手术治疗是胆管癌患者的首选方案,但手术也会面临着风险大、难点多等问题。近年研究发现,长链非编码RNA(lncRNA)和环状RNA(circRNA)具有调节胆管癌细胞增殖、转移、侵袭、上皮间质转化及耐药性等功能。文章综述lncRNA和circRNA在胆管癌发生、发展机制中的潜在调控作用,以期为胆管癌的早期诊断、靶向治疗及患者预后评估提供临床借鉴。

The insidious onset of cholangiocarcinoma and the lack of early diagnosis markers have made most patients diagnosed with cholangiocarcinoma in the advanced stage of the disease.At present,surgical treatment is the first choice for patients with cholangiocarcinoma,but surgery also faces problems such as high risks and many difficulties.Recent studies have found that long non-coding RNA(lncRNA)and circular RNA(circRNA)have the functions of regulating the cell proliferation,metastasis,invasion,epithelial-mesenchymal transition and drug resistance of cholangiocarcinoma.This article aims to review the potential regulatory role of lncRNA and circRNA in the occurrence and development of cholangiocarcinoma,in order to provide clinical references for the early diagnosis,targeted therapy and patient's prognosis evaluation of cholangiocarcinoma.