催眠疗法对老年失眠合并焦虑患者的睡眠质量及神经递质的影响

Effects of hypnotherapy on sleep quality and neurotransmitter in elderly patients with insomnia and anxiety

目的探讨催眠疗法对老年失眠合并焦虑患者的睡眠质量及神经递质的影响。方法选取我院2017年8月至2018年8月期间收治的118例老年失眠合并焦虑患者作为研究对象。按随机数字表法将研究对象随机分为观察组和对照组,对照组(59例)采用常规治疗手段,观察组(59例)对照组基础上联合催眠疗法,持续干预5周。观察干预5周后两组患者的临床疗效,以及干预前后患者的匹茨堡睡眠质量指数量表(PSQI)评分、汉密尔顿焦虑量表(HAMA)评分、睡眠进程参数指标和血清多巴胺(DA)、5-羟色胺(5-HT)、去甲肾上腺素(NE)等神经递质水平。结果 (1)观察组患者的总有效率为91.53%高于对照组的77.97%(P<0.05);(2)观察组干预后患者的PSQI评分和HAMA评分低于对照组(P<0.05);(3)观察组干预后患者的睡眠总时间、快速动眼期(REM)睡眠时间、睡眠效率高于对照组(P<0.05),睡眠潜伏期、觉醒时间低于对照组(P<0.05);(4)观察组干预后患者血清DA、5-HT、NE水平高于对照组(P<0.05)。结论催眠疗法干预老年失眠合并焦虑患者效果显著,可改善患者的睡眠质量,缓解其焦虑情绪,促进机体神经递质水平恢复,值得临床推广应用。

Objective To study the effect of hypnotherapy on sleep quality and neurotransmitters in elderly patients with insomnia and anxiety. Methods A total of 118 elderly patients with insomnia and anxiety admitted to our hospital from August 2017 to August 2018 were selected as study subjects. The subjects were randomly divided into the observation group and the control group according to the random number table method. The control group(59 cases)received conventional treatment,while the observation group(59 cases)received combined hypnotherapy on the basis of the control group,and the intervention lasted for 5 weeks. The clinical efficacy of the two groups after 5 weeks intervention,as well as the pittsburg sleep quality index(PSQI)score,Hamilton anxiety scale(HAMA)score,sleep process parameters and serum dopamine(DA),5-hydroxyht(5-HT),norepinephrine(NE)before and after the intervention were observed. Results (1)The total effective rate of 91.53% in the observation group was higher than 77.97% in the control group(P<0.05).(2)After intervention,PSQI and HAMA scores in the observation group were lower than those in the control group(P<0.05).(3)The total sleep time,rapid eye movement period(REM)sleep time and sleep efficiency in the observation group were higher than those in the control group(P<0.05),and the sleep latency and awakening time in the observation group were lower than those in the control group(P<0.05).(4)After intervention,the levels of DA,5-HT and NE in the observation group were higher than those in the control group(P<0.05). Conclusion Hypnotherapy has a remarkable effect on the elderly patients with insomnia and anxiety,which can improve the sleep quality of the patients,relieve their anxiety,and promote the recovery of the body’s neurotransmitter level,which is worthy of clinical popularization and application.