丁苯酞治疗脑梗死后抑郁患者的效果及对血清炎性因子水平的影响

Effect of butylphthalide on depression patients after cerebral infarction and its influence on serum inflammatory factors

目的探讨丁苯酞治疗脑梗死后抑郁患者的疗效及对血清炎性因子水平的影响。方法本研究的对象为我院2018年8月~2020年8月100例脑梗死后抑郁患者,随机分为对照组与观察组,对照组接受常规神经内科治疗并给予舍曲林进行抗抑郁治疗,观察组在对照组基础上联合丁苯酞治疗。比较治疗前后汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、运动功能评定量表(Fugl-Meyer)、美国国立卫生研究院卒中量表(NIHSS),检测治疗前后血清白细胞介素-6(IL-6)、IL-8以及C反应蛋白(CRP)水平。结果两组治疗后各项评分均显著改善,且治疗后观察组HAMD评分、HAMA评分、NIHSS评分均显著低于对照组,Fugl-Meyer评分显著高于对照组(P<0.05);两组治疗后血清IL-6、IL-8以及CRP水平均显著降低,且治疗后观察组显著低于对照组(P<0.05)。结论丁苯酞治疗脑梗死后抑郁能有效改善患者焦虑、抑郁情绪,并帮助患者提升神经及运动功能,降低血清炎性因子水平。

Objective To investigate the efficacy and effects of buphthalein on serum levels of inflammatory factors in treatment of post cerebral infarction depression patients. Methods A total of 100 patients with post cerebral infarction depression from August 2018 to August 2020 in our hospital were selected and randomly divided into a control group and an observation group. The control group received routine neurology treatment and was given sertraline for antidepressant treatment,and the observation group was combined with buphthalein treatment on a control group basis. The Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA),motor function rating scale(Fugl-Meyer),national institutes of health stroke scale(NIHSS)were compared between two groups before and after treatment,and serum levels of interleukin-6(IL-6),IL-8 as well as C-reactive protein(CRP)were detected. Results The patients in both of two group were significantly improved after treatment;The HAMD score,HAMA score,and NIHSS score were significantly in the observation group were lower than those in the control group after treatment(P<0.05). The Fugl Meyer scores in the observation group were higher than those in the control group(P<0.05). Serum levels of L-6,IL-8 as well as CRP were significantly decreased after treatment in both of two groups;the level of serum levels of L-6,IL-8 and CRP in the observation group were lower than those in the control group(P<0.05). Conclusion Buphthalein treatment of post cerebral infarction depression can effectively improve patients’ anxiety and depression,and help patients to improve their neurological and motor functions and reduce serum levels of inflammatory factors.