氟西汀联合双歧三联活菌对Hp阳性CAG伴焦虑抑郁患者心理状态、炎性因子水平及肠道菌群的影响

Effects of fluoxetine combined with bifid triple viable bacteria on mental state,inflammatory factor levels and intestinal flora in Hp-positive CAG patients with anxiety and depression

目的探究氟西汀联合双歧三联活菌对幽门螺杆菌(HP)阳性慢性萎缩性胃炎(CAG)伴焦虑抑郁患者的影响。方法选取我科2018年8月~2020年12月期间107例HP阳性CAG伴焦虑抑郁患者,采用信封法将其分为两组,两组均给予四联疗法联合双歧三联活菌治疗,对照组53例在此基础给予心理治疗,观察组54例增加氟西汀治疗,对比两组临床疗效、不良心理状态、炎性因子水平、肠道菌群。结果治疗后观察组的临床疗效、乳酸菌属、双歧杆菌属数量高于对照组,汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分、白细胞介素6(IL-6)、C反应蛋白(CRP)及肿瘤坏死因子α(TNF-α)、大肠埃希菌、梭菌属、拟杆菌属水平低于对照组(P<0.05)。结论双歧三联活菌联合氟西汀可以明显提高Hp阳性CAG伴焦虑抑郁患者治疗效果,通过改善患者焦虑、抑郁状态,降低机体内炎性因子水平,改善机体内肠道菌群数量。

Objective To explore the effect of fluoxetine combined with viable bifidus triple bacteria on Helicobacter pylori(HP)-positive chronic atrophic gastritis(CAG)patients with anxiety and depression. Methods Selected 107 HP-positive CAG patients with anxiety and depression in our department from August 2018 to December 2020,and divided them into two groups using the envelope method. Both groups were given quadruple therapy combined with bifid triple viable treatment. The 53 cases in the control group were given psychotherapy,and the 54 cases in the observation group were treated with fluoxetine. The clinical efficacy,adverse mental state,levels of inflammatory factors,and intestinal flora were compared between the two groups. Results After treatment,the clinical efficacy,number of lactic acid bacteria and bifidobacteria in the observation group were higher than those in the control group,Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)scores,interleukin 6(IL-6),The levels of C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α),Escherichia coli,Clostridium,and Bacteroides were lower than those in the control group(P<0.05). Conclusion The combination of bifid triple viable bacteria combined with fluoxetine can significantly improve the treatment effect of patients with Hp-positive CAG with anxiety and depression,by improving the patients’ anxiety and depression,reducing the level of inflammatory factors in the body,and improving the number of intestinal flora in the body.