鼻塞式同步间歇指令通气联合猪肺磷脂注射液治疗新生儿肺透明膜病的效果及安全性研究

Study on the Effect and Safety of Nasal Synchronized Intermittent Mandatory Ventilation Combined with Poractant Alfa Injection in the Treatment of Neonatal Hyaline Membrane Disease

目的探讨鼻塞式同步间歇指令通气联合猪肺磷脂注射液治疗新生儿肺透明膜病(HMD)的效果及安全性。方法100例HMD新生儿随机分为两组各50例,对照组采用鼻塞式同步间歇指令通气治疗,干预组在对照组基础上采用猪肺磷脂注射液治疗,比较两组的临床疗效、血氧指标、呼吸力学指标以及不良反应。结果干预组的总有效率为94.00%,显著高于对照组的76.00%(P<0.05)。治疗后,干预组的pH、PaO2、PaCO2、SaO2以及Cstat、Insp Flow、Rcexp均显著优于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论鼻塞式同步间歇指令通气联合猪肺磷脂注射液治疗新生儿HMD具有显著的临床效果,安全性高,可有效改善新生儿血氧指标及呼吸力学指标。

Objective To explore the effect and safety of nasal synchronized intermittent mandatory ventilation combined with poractant alfa injection in the treatment of neonatal hyaline membrane disease(HMD).Methods 100 neonates with HMD were randomly divided into two groups,with 50 cases in each group.The control group was treated with nasal synchronized intermittent mandatory ventilation,and the intervention group was treated with poractant alfa injection on the basis of the control group.The clinical efficacy,blood oxygen indicators,respiratory mechanics indicators and adverse reactions were compared between the two groups.Results The total effective rate of the intervention group was 94.00%,significantly higher than 76.00%of the control group(P<0.05).After treatment,the pH,PaO2,PaCO2,SaO2,Cstat,Insp Flow and Rcexp of the intervention group were significantly better than those of the control group(P<0.05).No significant difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Nasal synchronized intermittent mandatory ventilation combined with poractant alfa injection in the treatment of neonatal HMD has significant clinical effect and high safety,and can effectively improve neonatal blood oxygen indicators and respiratory mechanics indicators.