Spadin及其类似物治疗脑卒中后抑郁的研究进展

Recent advance in Spadin and its analogs in treatment of post-stroke depression

脑卒中后抑郁(PSD)是脑卒中后常见的精神疾病之一,预防和治疗工作均存在一定难度。双孔钾离子通道TREK-1是脑卒中和PSD发病机制中的一个重要靶点,与神经保护以及情绪的调控密切相关,抑制TREK-1通道的活性能够发挥明显抗抑郁效果。近年来研究发现TREK-1通道阻滞剂Spadin及其类似物对于治疗缺血性脑卒中以及PSD有较好疗效。本文现围绕Spadin及其类似物的发现、作用及其对PSD的治疗价值等内容综述如下。

Post-stroke depression(PSD)is one kind of the common mental diseases after stroke,and the prevention and treatment of PSD are very difficult.TREK-1,a two-pore domain potassium channel,is an important target in the pathogenesis of stroke and PSD,and it is closely related to neuroprotection and emotion regulation;inhibition of activity of TREK-1 channel can exert significant antidepressant effect.In recent years,TREK-1 channel blocker Spadin and Spadin analogs are discovered,and they have a relatively significant effect on ischemic stroke and PSD.In this paper,the research progress on the discovery,efficacy and therapeutic value of Spadin and Spadin analogs in PSD are summarized as follows.