富含血小板血浆治疗宫腔粘连的效果分析

Clinical Outcome Analysis of Platelet-Rich Plasma(PRP)in Treating Intrauterine Adhesions(IUAs)

目的评估富含血小板血浆(platelet-rich plasma,PRP)在治疗宫腔粘连中的作用。方法回顾性分析2018年4月—2020年6月于中山大学附属第六医院因中度及重度宫腔粘连行手术的患者,其中A组为第一次宫腔镜手术术后使用宫腔注射PRP的43名患者,B组为第一次宫腔镜手术术后使用宫腔球囊支架的32名患者。进行第三次宫腔镜手术复查的患者中,A组33名,B组22名,统计两组患者第一次手术、第三次手术的宫腔粘连AFS评分,并统计行胚胎移植的患者的生化妊娠率。结果A组患者宫腔粘连AFS评分由(7.82±1.62)分降至(2.82±1.95)分,B组患者宫腔粘连AFS评分由(8.09±1.85)分降至(3.18±1.75)分,两组患者在第一次手术及第三次手术中AFS评分差异无统计学意义(P>0.05)。A组及B组的生化妊娠率分别为40.0%及38.9%,组间差异无统计学意义(P>0.05)。结论宫腔内注射PRP是治疗宫腔粘连的一种新方法。

Objective To evaluate the efficacy of an intrauterine infusion of platelet-rich plasma(PRP)in patients with intrauterine adhesions(IUAs).Methods This is a retrospective cohort study in the sixth affiliated hospital of Sun Yat-Sen university from April 2018 to June 2020,and 43 patients with intrauterine infusion of PRP(group A),32 patients with intrauterine balloon(group B)in the first hysteroscopy were included.All patients were with moderate of severe IUAs.In this study,33 patients in group A and 22 patients in group B received the third-look hysteroscopy.Mean AFS score and chemical pregnancy rates were compared between these two groups.Results The mean AFS score decreased from(7.82±1.62)points in the first hysteroscopy to(2.82±1.95)points in the third hysteroscopy in group A,and from(8.09±1.85)points to(3.18±1.75)points in group B.No significant differences were found between these groups(P>0.05).The chemical pregnancy rates were 40.0%in group A and 38.9%in group B,there was no significant difference between the groups(P>0.05).Conclusion Intrauterine infusion of PRP is a new treatment method in the management of patients with IUAs.