叶酸联合维生素B_(12)对儿童癫痫患者同型半胱氨酸水平的影响

Effect of Folic Acid Combined with Vitamin B_(12) on Homocysteine Levels in Children with Epilepsy

目的:观察叶酸联合维生素B_(12)对儿童癫痫患者同型半胱氨酸(Hcy)水平的影响。方法:选取我院2017年1月—2020年12月就诊,接受治疗的98例儿童癫痫患者为研究对象。按照随机数字表,将98例患者随机分为干预组和对照组各49例,两组患者性别、年龄、病程、发病频率间均无差异(P>0.05),具有可比性。对照组患者选择临床一线治疗药物进行抗癫痫治疗,干预组患者在对照组用药基础上,添加0.4 mg叶酸+100μg维生素B_(12)进行辅助治疗,对患者进行为期3个月的跟踪随访。测定两组患者干预前、干预1个月、干预3个月后血清Hcy、叶酸和维生素B_(12)水平,比较两者患者干预前后血清Hcy、叶酸和维生素B_(12)水平变化,同时记录患者癫痫发作次数和每次发作持续时间,比较两者患者发作次数和持续时间的差异。结果:治疗前,两组患者血清Hcy、叶酸和维生素B_(12)水平比较均无统计学差异。经叶酸联合维生素B_(12)干预1个月、3个月后,干预组患者血清Hcy水平均显著降低(P<0.05),叶酸及维生素B_(12)水平均显著增高(P<0.05),而对照组患者血清Hcy水平出现增高现象(P<0.05),叶酸及维生素B_(12)水平未观察到差异(P>0.05),干预组与对照组相比,血清Hcy、叶酸和维生素B_(12)水平均有差异(P<0.05);干预组患者癫痫发作频率显著低于对照组患者,发作持续时间显著短于对照组患者(P<0.001)。结论:叶酸联合维生素B_(12)对儿童癫痫患者进行辅助治疗,可显著降低血清Hcy水平,降低癫痫发作频率,缩短癫痫发作时间,值得在临床推广应用。

Objective To observe the effect of folic acid combined with vitamin B_(12)on the level of homocysteine(Hcy)in children with epilepsy.Method We selected 98 cases of childhood epilepsy patients treated in our hospital from January 2017 to December 2020 as the research objects.According to the random number table,98 patients were randomly divided into the intervention group and the control group,each with 49 cases.There was no difference in gender,age,course of disease,and frequency of disease between the two groups(P>0.05).Patients in the control group chose clinical first-line drugs for anti-epileptic treatment.Patients in the intervention group were treated with 0.4 mg folic acid+100μg vitamin B_(12)for adjuvant therapy based on the drugs in the control group.The patients were followed up for a period of 3 months.The serum Hcy,folic acid and vitamin B_(12)levels of the two groups patients before intervention,one month and three months after intervention were measured,and the changes in serum Hcy,folic acid and vitamin B_(12)levels of the two patients before and after intervention were compared.At the same time,the frequency of seizures and the duration of each seizure were recorded,and the difference in the frequency and duration of seizures between the two patients was compared.Result Before treatment,there was no statistical difference between the two groups of patients in serum Hcy,folic acid and vitamin B_(12)levels.After folic acid combined with vitamin B_(12)intervention for one and three months,serum Hcy levels of intervention group patients were significantly reduced(P<0.05),folic acid and vitamin B_(12)levels were significantly increased(P<0.05),while serum Hcy levels of patients in the control group was increased(P<0.05),folic acid and vitamin B_(12)levels was no difference observed(P>0.05).Compared with the control group,the intervention group had differences in serum Hcy,folic acid and vitamin B_(12)levels(P<0.05).The frequency of seizures in the intervention group was significantly lower than that in the control group,and the duration of seizures was significantly shorter than that of the control group(P<0.001).Conclusion Folic acid combined with vitamin B_(12)for adjuvant treatment of children with epilepsy can significantly reduce serum Hcy levels,reduce the frequency of seizures,and shorten the duration of seizures.It is worthy of clinical application.