低温等离子射频消融术对鼾症患儿血清ET-1、GMP-140、NO水平的影响

Effect of low-temperature plasma radiofrequency ablation on serum ET-1,GMP-140 and NO levels in children with snoring

目的探讨低温等离子射频消融术对鼾症患儿血清内皮素-1(ET-1)、血小板膜蛋白-140(GMP-140)、一氧化氮(NO)水平的影响。方法选取2020年5月至2021年2月上饶市立医院收治的176例鼾症患儿作为研究对象,按照随机数字表法分为观察组(88例)与对照组(88例),对照组采用扁桃体切除术+鼻内镜下腺样体切除术治疗,观察组采用低温等离子射频消融术治疗。采用魁北克睡眠问卷(QSQ)、爱泼沃斯嗜睡量表(ESS)评估患儿睡眠质量,比较两组患儿的围手术期指标、睡眠质量、血管内皮功能。结果观察组的手术时间、疼痛时间、症状缓解时间短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05);观察组的QSQ评分高于对照组,ESS评分低于对照组,差异有统计学意义(P<0.05);观察组的ET-1、GMP-140水平均低于对照组,NO水平高于对照组,差异有统计学意义(P<0.05)。结论鼾症患儿应用低温等离子射频消融术,治疗优势显著,能够减少出血量,减轻术后疼痛感受,促进症状缓解,可有效改善患儿睡眠质量,有助于血管内皮功能恢复,值得临床广泛开展。

Objective To investigate the effect of low-temperature plasma radiofrequency ablation on serum endothelin-1(ET-1),platelet membrane protein-140(GMP-140)and nitric oxide(NO)levels in children with snoring.Methods A total of 176 children with snoring admitted to Shangrao Municipal Hospital from May 2020 to February 2021 were selected as the study subjects,and divided into the observation group(88 cases)and the control group(88 cases)according to the random number table method.The control group was treated with tonsillectomy+nasal endoscopic adenoidectomy,and the observation group was treated with low-temperature plasma radiofrequential ablation.Quebec sleep questionnaire(QSQ)and Epworth sleepiness scale(ESS)were used to evaluate the sleep quality of the children,and the perioperative indicators,sleep quality and vascular endothelial function of the two groups were compared.Results The operative time,pain time and symptom relief time of the observation group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant(P<0.05).QSQ score of the observation group was higher than that of the control group,and ESS score was lower than that of the control group,the differences were statistically significant(P<0.05).The levels of ET-1 and GMP-140 in the observation group were lower than those in the control group,and the level of NO was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion The application of low-temperature plasma radiofrequency ablation for children with snoring has significant therapeutic advantages.It can reduce bleeding,relieve postoperative pain,and promote symptom relief.It can also effectively improve the quality of sleep in children and help the recovery of vascular endothelial function,and is an ideal treatment option,which is worthy of extensive clinical practice.