血清BGP水平与甲状腺功能亢进甲状腺激素的相关性

Correlation Between Serum BGP Level and Thyroid Hormone in Patients with Hyperthyroidism

目的分析血清骨钙素(BGP)水平与甲状腺功能亢进(甲亢)患者甲状腺激素的相关性。方法前瞻性选取我院2018年2月至2020年2月收治的60例甲亢患者,均采用甲巯咪唑片、盐酸普萘洛尔片治疗,记录治疗前以及治疗3个月后的BGP及甲状腺激素指标[游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)],并分析BGP与FT3、FT4、TSH的相关性。结果治疗3个月后,患者血清FT3、FT4、BGP水平较治疗前低,TSH水平较治疗前高,差异有统计学意义(P<0.05);采用一般线性双变量Pearson相关性检验,结果显示,血清BGP水平和FT3、FT4呈正相关(r>0,P<0.05),和TSH呈负相关(r<0,P<0.05)。结论甲亢患者的血清BGP水平和甲状腺激素水平密切相关,随着甲状腺激素水平趋于正常,血清BGP水平逐渐降低。

Objective To analyze the correlation between serum osteocalcin(BGP)level and thyroid hormone in patients with thyroid hyperfunction(hyperthyroidism).Methods 60 patients with hyperthyroidism treated in our hospital from February 2018 to February 2020 were prospectively selected,all patients were treated with Thiamazole Tablets and Propranolol Hydrochloride Tablets,BGP and thyroid hormone indexes[free triiodothyronine(FT3),serum free thyroxine(FT4),thyroid stimulating hormone(TSH)]were recorded before and 3 months after treatment,and the correlation between BGP and FT3,FT4,TSH was analyzed.Results After 3 months of treatment,the serum FT3,FT4 and BGP levels of patients were lower than those before treatment,and the TSH level was higher than that before treatment,the differences were statistically significant(P<0.05);the general linear bivariate Pearson correlation test was used,the results showed that serum BGP level was positively correlated with FT3 and FT4(r>0,P<0.05),and negatively correlated with TSH(r<0,P<0.05).Conclusion Serum BGP level is closely related to thyroid hormone level in patients with hyperthyroidism,as the thyroid hormone level tends to be normal,the serum BGP level is gradually decreased.